Clinical Value of Left Atrial Appendage Flow for Prediction of Successful Catheter Ablation for Persistent Atrial Fibrillation (CLAAAF)
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Purpose
The purpose of this study was to determine whether left atrial appendage flow velocity, as determined using trans esophageal echocardiography (TEE), predicts the outcome after catheter ablation of persistent Atrial fibrillation( pAF).
| Condition | Intervention |
|---|---|
|
Persistent Atrial Fibrillation Catheter Ablation |
Other: a complete transesophageal echocardiography |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Clinical Value of Left Atrial Appendage Flow for Prediction of Successful Catheter Ablation for Persistent Atrial Fibrillation |
- termination of persistent AF by catheter ablation [ Designated as safety issue: Yes ]
- Recurrences of AF were therefore determined from holter monitoring at 3 and 6 months or 12 leads ECG in care of symptomatic palpitation with clinical interview. [ Designated as safety issue: Yes ]
| Enrollment: | 40 |
| Study Start Date: | January 2009 |
| Study Completion Date: | December 2009 |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| patients with persistent atrial fibrillation ablation |
Other: a complete transesophageal echocardiography
All patients were evaluated by a complete transesophageal echocardiography with multiplane probes with a 7-MHz transducer before catheter ablation .LA appendage flow was obtained by placing the pulsed Doppler sample volume at the orifice of the LA appendage, after which peak flow velocities were measured and averaged within each RR interval of 10 consecutive cardiac cycles
|
Detailed Description:
40 PAF patients underwent 3D mapping and ablation. A stepwise approach including circumferential pulmonary vein (PV) isolation, continuous complex-fractionated electrogram (CFE) ablation and linear ablation was performed by the same operator. The procedural end point was termination of persistent AF by catheter ablation, either by conversion directly to sinus rhythm or to atrial tachycardia. Left atrial appendage (LAA) peak flow velocities were measured with transesophageal echography and averaged within each RR interval of 10 consecutive cardiac cycles.
Eligibility| Ages Eligible for Study: | 18 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Sampling Method: | Probability Sample |
40 consecutive patients who underwent first-time radiofrequency catheter ablation for pAF. pAF was defined as continuous AF lasting longer than 1 month, resistant to either electrical or pharmacological cardioversion
Inclusion Criteria:
- First-time radiofrequency catheter ablation for pAF. pAF was defined as continuous AF lasting longer than 1 month, resistant to either electrical or pharmacological cardioversion.
- Informed consent
Exclusion Criteria:
- Severe valvular disease requiring surgery
- Valvular prosthesis
- Known severe coronary artery disease
- Atrial and/or ventricular thrombosis
- New York Heart Association functional class III to IV
- Cerebrovascular disease
- Pulmonary embolism
- Latent or manifest hyperthyroidism
Contacts and Locations More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT01144858 History of Changes |
| Other Study ID Numbers: | past-1001-ryth |
| Study First Received: | June 15, 2010 |
| Last Updated: | June 15, 2010 |
| Health Authority: | France: Direction Générale de la Santé |
Keywords provided by Clinique Pasteur:
|
atrial fibrillation ablation catheter left atrial appendage peak emptying velocity tool for predicting successful catheter ablation |
Additional relevant MeSH terms:
|
Atrial Fibrillation Arrhythmias, Cardiac Heart Diseases Cardiovascular Diseases Pathologic Processes |
ClinicalTrials.gov processed this record on May 19, 2013