Chlorhexidine Mouthrinses and Plaque Control
The aim of the present study was to compare antiplaque effectiveness of two commercial mouthrinses: 0.12 % Chlorhexidine alcohol base (CLX-A) versus a diluted 0.1% Chlorhexidine non-alcohol base with 0.1% of Formaldehyde (CLX-F).
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Prevention
|Official Title:||Chlorhexidine Alcohol Base Mouthrinse Versus Chlorhexidine Formaldehyde Base Mouthrinse Efficacy on Plaque Control: Double Blind, Randomized Clinical Trials|
- Plaque Index (PI)at Day 1 and Day 7. [ Time Frame: one week ] [ Designated as safety issue: No ]
The clinical trial lasted 7 days (from Day 0 to Day 7). During this period all participants abstained from all mechanical oral hygiene procedures.
On Day 0, subjects were randomly distributed in three groups: two test groups and one negative control group, and were instructed to rinse twice daily with the allocated mouthrinse during the experimental period.
The clinical measurement: Plaque Index (PI) was recorded on Day 1 and Day 7.
- Side effects [ Time Frame: at day 7 ] [ Designated as safety issue: No ]On Day 7, all subjects were examined for the presence or absence of tooth staining, and were questioned about taste disturbances and mucosal sensitivities.
|Study Start Date:||February 2007|
|Study Completion Date:||April 2007|
|Primary Completion Date:||March 2007 (Final data collection date for primary outcome measure)|
|Active Comparator: Chlorhexidine alcohol-base mouthrinse||
15 ml, tree times/day for 07 days
Arm: Chlorhexidine alcohol-base mouthrinse
Other Name: Synthodont
|Experimental: non alcohol chlorhexidine mouthrinse||
15ml of 01% Chlorhexidine non alcohol-based, 3 times a day for 7 days
Arm: Experimental: non alcohol chlorhexidine mouthrinse
Other Name: Soludent
Chlorhexidine (CLX) mouthrinse has been the gold standard as antiplaque solution.However, if its efficiency seems to be preserved even if the chlorhexidine concentration is bellow 0.10%, the formulation of the final product may affect the effectiveness. Thus, it can be concluded from this study that 0.12% CLX alcohol base mouthrinse is significantly more effective in inhibiting plaque than the diluted 0.1% CLX non-alcohol base containing formaldehyde mouthrinse.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01138943
|Faculté de Médecine Dentaire|
|Rabat, Morocco, 10 000|
|Study Chair:||Oumkeltoum Ennibi, Professor||Faculté de Médecine Dentaire|