Biomarkers in Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in tissue samples from young patients with acute myeloid leukemia.
|Official Title:||Stat3 Signaling Pathway Aberrancies in Pediatric AML|
- Correlations between levels of pY-Stat3 and levels of upstream cytokine receptors [ Designated as safety issue: No ]
- Association of constitutive and/or increased pY-Stat3 and c-kit genotype [ Designated as safety issue: No ]
|Study Start Date:||September 2009|
|Primary Completion Date:||March 2010 (Final data collection date for primary outcome measure)|
- Determine the frequency of ligand-independent phosphorylation of Stat3 in a small cohort of samples from pediatric patients with acute myeloid leukemia including, but not limited to, samples known to express mutated c-kit.
- Measure the level of Stat3 phosphorylation in these samples after stimulation of three key cytokine receptors expressed on hematopoietic cells IL-6R, G-CSFR, and c-kit.
OUTLINE: Cryopreserved samples are analyzed for levels of various components of the Stat3 pathway via western blotting.
|Principal Investigator:||Michele S. Redell, MD, PhD||Texas Children's Cancer Center|