Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

• Tissue, blood, and body fluid samples collection for ongoing diagnostic, prognostic, or immune-monitoring studies [ Time Frame: 30 years ] [ Designated as safety issue: No ]
  
• Development of a centralized, quality-controlled, quality-assured facility for the procurement, processing, storage, and distribution of normal and malignant tissue specimens and corresponding blood specimens [ Time Frame: 30 years ] [ Designated as safety issue: No ]
  

Other: biologic sample preservation procedure
All samples collected during routine clinical care.
Other: cytology specimen collection procedure
All Samples collected during routine clinical care.

OBJECTIVES:

• Provide source of patient tissue, blood, and body fluid samples for ongoing diagnostic, prognostic, or immune-monitoring studies.
• Support and enhance translational, clinical and basic research for Lineberger Comprehensive Cancer Center (LCCC) members (and non-members who have an LCCC member as sponsor and collaborator) with IRB-approved studies.
• Maintain responsible and appropriate policies and procedures that ensure good patient care and responsible conduct of research.
• Address medical and legal issues, and protect participant and patient privacy and confidentiality.
• Provide a responsible and uniform mechanism for the integrated coordination of the hemato-pathologist and surgeon or hematology/oncology staff, researcher, and protocol office to obtain appropriate specimens for researchers.
• Support young investigators to obtain pilot data for grant funding.

OUTLINE: Patients undergo tissue, blood, and body fluid collection during diagnostic or routine procedures for future correlative studies. Tissue samples may include, but are not limited to, lymph node or non-nodal biopsies, bone marrow biopsy and/or aspirate, blood and serum, and buccal swabs for germline DNA analysis.