The Impact of Vitamin D on Tuberculosis Among Koreans

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Jae-Joon Yim, Seoul National University Hospital
ClinicalTrials.gov Identifier:
NCT01137370
First received: June 3, 2010
Last updated: January 3, 2014
Last verified: January 2014
  Purpose

Vitamin D has been regarded to be beneficial to tuberculosis (TB) patients. The aim of this study is to elucidate the role of vitamin D deficiency in development and treatment outcomes among Korean TB patients. Furthermore, the impact of genotypes of vitamin D receptor gene on TB development will also be evaluated.


Condition
Tuberculosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Impact of Vitamin D Level and Single Nucleotide Polymorphisms of Vitamin D Receptor Gene on the Development and Treatment Response of Tuberculosis

Resource links provided by NLM:


Further study details as provided by Seoul National University Hospital:

Primary Outcome Measures:
  • Prevalence of Vitamin D Deficiency [ Time Frame: At enrollment ] [ Designated as safety issue: Yes ]
  • Median 25-OHD Level [ Time Frame: August 2010 to March 2011 ] [ Designated as safety issue: Yes ]

Biospecimen Retention:   Samples With DNA

Serums for vitamin D measurement DNA for genotyping of vitamin D receptor gene


Enrollment: 203
Study Start Date: January 2010
Study Completion Date: April 2011
Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
Patients with TB
People without TB

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Patients diagnosed and treated as having a TB in Seoul National University Hospital

Criteria

Inclusion Criteria:

  • older than 19 years
  • diagnosed and treated having a tuberculosis

Exclusion Criteria:

  • positive HIV antibody
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01137370

Locations
Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of, 110-744
Sponsors and Collaborators
Seoul National University Hospital
  More Information

No publications provided

Responsible Party: Jae-Joon Yim, Professor, Seoul National University Hospital
ClinicalTrials.gov Identifier: NCT01137370     History of Changes
Other Study ID Numbers: H-0911-066-301
Study First Received: June 3, 2010
Results First Received: January 3, 2014
Last Updated: January 3, 2014
Health Authority: South Korea: Institutional Review Board

Additional relevant MeSH terms:
Tuberculosis
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Vitamin D
Vitamins
Bone Density Conservation Agents
Physiological Effects of Drugs
Pharmacologic Actions
Micronutrients
Growth Substances

ClinicalTrials.gov processed this record on April 17, 2014