Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure (MAES)

This study has been completed.
Sponsor:
Collaborator:
Arla Foods
Information provided by:
University of Copenhagen
ClinicalTrials.gov Identifier:
NCT01133964
First received: May 27, 2010
Last updated: June 23, 2011
Last verified: September 2008
  Purpose

The aim of this study is to examine the effect of dairy proteins (whey and casein) on postprandial appetite regulation and energy expenditure.


Condition Intervention
Obesity
Dietary Supplement: dairy proteins

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Prevention
Official Title: Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure

Further study details as provided by University of Copenhagen:

Primary Outcome Measures:
  • Subjective appetite sensation [ Time Frame: 5 hours ] [ Designated as safety issue: No ]
  • Energy expenditure [ Time Frame: 5 hours ] [ Designated as safety issue: No ]
  • Substrate oxidation [ Time Frame: 5 hours ] [ Designated as safety issue: No ]

Enrollment: 22
Study Start Date: October 2008
Study Completion Date: December 2009
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: milk
skim milk
Dietary Supplement: dairy proteins
Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.
Experimental: casein drink Dietary Supplement: dairy proteins
Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.
Experimental: whey drink Dietary Supplement: dairy proteins
Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.
Sham Comparator: water Dietary Supplement: dairy proteins
Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.

Detailed Description:

Several studies have shown that a high protein intake is associated with a increased loss of body weight and body fat as compared to a diet with a normal or low protein content. The effect seems to be due to a higher diet induced thermogenesis and increase satiety.

Milk has a high content of proteins. It contains two very different types of protein: whey and casein. Whey is a soluble protein whereas casein clots into the stomach, which delays its gastric emptying and thus probably results in a slower release of amino acids. It is therefore very likely that the two types of protein affect the thermogenesis and appetite regulation differently.

The aim of the present study is to examine the effect of dairy proteins (whey and casein) on postprandial energy expenditure, substrate oxidation and appetite regulation.

The study will have a cross-over design including four meals each including a test drink (milk, casein drink, whey drink or water).

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy males
  • body mass index (BMI) 25-30 kg/m2
  • 18-50 years
  • weight stable

Exclusion Criteria:

  • smoker
  • regular use of medicine
  • elitist athletes
  • participation in other intervention studies
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01133964

Locations
Denmark
Department og Human Nutrition, Life, University of Copenhagen
Copenhagen, Denmark, 1958
Sponsors and Collaborators
University of Copenhagen
Arla Foods
Investigators
Principal Investigator: Arne Astrup, Dr. Department of Human Nutrition, Life, University of Copenhagen
  More Information

No publications provided

Responsible Party: Janne Kunchel Lorenzen, Cand. Scient., Department of Human Nutrition, Life, University of Copenhagen
ClinicalTrials.gov Identifier: NCT01133964     History of Changes
Other Study ID Numbers: B256
Study First Received: May 27, 2010
Last Updated: June 23, 2011
Health Authority: Denmark: Ethics Committee
Denmark: Danish Dataprotection Agency

Keywords provided by University of Copenhagen:
Dairy proteins
Appetite regulation
Energy expenditure

ClinicalTrials.gov processed this record on October 23, 2014