Role of Inflammation in Progressive Multifocal Leukoencephalopathy (PML)
This is a continuation of our previous studies on Progressive Multifocal Leukoencephalopathy (PML). We will focus on the role of inflammation in PML, and define prognostic markers of disease evolution.
Progressive Multifocal Leukoencephalopathy
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Role of Inflammation in PML|
Blood, Urine, CSF if needed for clinical management.
|Study Start Date:||June 2004|
|Estimated Study Completion Date:||September 2013|
These are subjects who have confirmed PML.
These are subjects who do not have PML. They may be healthy or immune compromised due to Cancer, Transplant, or HIV.
To determine precisely what are the host or viral factors that may predict a favorable outcome for PML patients and the role of inflammation in preventing JCV from causing brain disease. One of the goals of this study is to help establish non-invasive markers of PML evolution by studying the brain metabolism in PML lesions using Magnetic Resonance Imaging (MRI), Magnetic Spectroscopy (MRS) and other advanced imaging modalities.
|United States, Massachusetts|
|Beth Israel Deaconess Medical Center|
|Boston, Massachusetts, United States, 02215|
|Principal Investigator:||Igor J Koralnik, MD||Beth Israel Deaconess Medical Center|