Immunological Change and the Single Nucleotide Polymorphism (SNP) in Children With Irritable Bowel Syndrome (IBS)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2010 by Chang Gung Memorial Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier:
NCT01131442
First received: May 25, 2010
Last updated: May 26, 2010
Last verified: May 2010
  Purpose

Currently, the pathophysiology of Irritable bowel syndrome( IBS) remains unclear . The purpose of this study is want to investigate the immunological changes in the children with IBS.


Condition
Irritable Bowel Syndrome
Children

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional

Resource links provided by NLM:


Further study details as provided by Chang Gung Memorial Hospital:

Estimated Enrollment: 40
Study Start Date: November 2008
Groups/Cohorts
The patient group
healthy control group

Detailed Description:

Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder.Many children suffered from this disease and had impact on their daily life. However, the underlying pathophysiologic mechanisms remain to be elucidate. Dysregulation of the gut immune system is considered an important pathophysiology. We want to investigate the immunological changes in the IBS children.

  Eligibility

Ages Eligible for Study:   5 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

out patient clinics in the hospital

Criteria

Inclusion Criteria:

  • (5-18y/o) with IBS,
  • All patients had chronic or relapsing symptoms of IBS consistent with the ROME II criteria

Exclusion Criteria:

  • A history of psychologic disorders, probiotics, anti-inflammatory, analgesic, or immunosuppressive medication (nonsteroidal anti-inflammatory drugs, steroids) within the past 3 months were excluded
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01131442

Locations
Taiwan
Chang Gung Memeorial Hospital Recruiting
Keelung, Taiwan
Contact: Man-Chin Hua, M.D.    886-2-24313131 ext 2626    menchinhua@gmail.com   
Principal Investigator: Man-Chin Hua Hua, M.D.         
Sponsors and Collaborators
Chang Gung Memorial Hospital
  More Information

No publications provided by Chang Gung Memorial Hospital

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier: NCT01131442     History of Changes
Other Study ID Numbers: CMRPG270371
Study First Received: May 25, 2010
Last Updated: May 26, 2010
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Chang Gung Memorial Hospital:
immune

Additional relevant MeSH terms:
Irritable Bowel Syndrome
Syndrome
Colonic Diseases
Colonic Diseases, Functional
Digestive System Diseases
Disease
Gastrointestinal Diseases
Intestinal Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on October 23, 2014