Saliva Composition and Oral Hygiene in Children With Celiac Disease Before and After the Change in Diet

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Moti Moskovitz, Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT01129908
First received: May 23, 2010
Last updated: July 21, 2012
Last verified: July 2012
  Purpose

The celiac disease (CD) is a disease with an immune and genetic component that is activated by the presence of gluten, and damages the intestine mucosa and causes malabsorption of food.

In the oral environment the investigators see enamel defects and recurrent ulcers.

Celiac patients have to keep a restrict gluten-free diet, in order to prevent the clinical symptoms of the disease (such as diarrhea, stomach ache and weight loss).

It has been assumed that the patients have less cariogenic diet, and that caries prevalence is not as high as in normal population.

In celiac patients the investigators find enamel defects that are characterized with pits and deep fissures and sometimes the complete loss of enamel. These defects are classified by the grading of the CD related DED's (dental enamel defects) according to Aine. These defects are symmetrical defects in the permanent dentition, in teeth that develops at the same time. The cause is thought to be hypocalcaemia or genetic.

These defects were found in 42.2% of celiac patients in appose to only 5.4% in healthy population.

Recurrent ulcers were found in 41% in the oral cavity of celiac patients, compare to 27% in healthy population.

After changing the diet to a gluten-free diet, an improvement is seen in the presence of these ulcers.


Condition
Celiac Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Saliva Composition and Oral Hygiene in Children With Celiac Disease Before and After the Change in Diet

Resource links provided by NLM:


Further study details as provided by Hadassah Medical Organization:

Enrollment: 90
Study Start Date: May 2010
Study Completion Date: July 2012
  Eligibility

Ages Eligible for Study:   3 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

chilren with celiac disease

Criteria

Inclusion Criteria:

  • celiac disease

Exclusion Criteria:

  • no other systemic condition
  • age 3-18
  • children on medication
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Moti Moskovitz, Clinical Senior Lecturer, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT01129908     History of Changes
Other Study ID Numbers: odelia- HMO-CTIL
Study First Received: May 23, 2010
Last Updated: July 21, 2012
Health Authority: Ministry of Health - Director General: Israel

Keywords provided by Hadassah Medical Organization:
oral health in children with celiac disease

Additional relevant MeSH terms:
Celiac Disease
Digestive System Diseases
Gastrointestinal Diseases
Intestinal Diseases
Malabsorption Syndromes
Metabolic Diseases

ClinicalTrials.gov processed this record on October 29, 2014