Influence of Adiponutrin in Chronic Liver Disease
Increasing evidence attests the influence of multiple metabolic genetic risk factors in the progression of alcoholic liver disease. Deleterious pathways involved in metabolism such as lipid peroxidation and cytokines have been implicated in promoting inflammation leading to fibrosis increase and liver injury progression. The aim of this study was to assess the role of rs738409 single nucleotide polymorphism in the PNPLA3 gene in alcoholic liver disease patients.
Alcoholic Liver Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Study of Metabolism Influence in Human Alcoholic Liver Disease|
- Assessment of fibrosis and steatosis by liver biopsy in alcoholic liver disease patients.After liver histology assessment for liver liver dammage a potential correlation of fibrosis and steatosis was studied with rs738409 PNPLA3 polymorphism
Biospecimen Retention: Samples With DNA
DNA extraction from whole blood sample. Piece of liver tissue in the alcoholic liver disease group.
|Study Start Date:||January 2003|
|Study Completion Date:||March 2010|
|Primary Completion Date:||January 2010 (Final data collection date for primary outcome measure)|
Alcoholic liver disease
Alcoholic liver disease patients undergoing a transjugular liver biopsy in our institution
Healthy controls patients recruited from the Occupational Medicine Department during a routine physical examination.