Characterization and Differential Diagnosis of Postneurosurgical Meningitis
Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Clinical Features, Microbiological Characteristics, and Differential Diagnosis of Postneurosurgical Meningitis|
- Development of meningitis [ Time Frame: within 4 weeks after neurosurgical operation ] [ Designated as safety issue: No ]
- All-cause mortality [ Time Frame: within 4 weeks after the diagnosis of meningitis ] [ Designated as safety issue: No ]
|Study Start Date:||May 2010|
|Study Completion Date:||September 2013|
|Primary Completion Date:||September 2013 (Final data collection date for primary outcome measure)|
Besides description of characteristics of patients with postneurosurgical patients, we also will investigate the usefulness of prolonged cerebrospinal fluid (CSF) culture, and profiles of blood and CSF inflammatory markers for the differential diagnosis of meningitis. CSF culture will be extended upto 2 weeks. Serum procalcitonin and C-reactive protein, CSF adenosine deaminase levels will be monitored and analyzed for the differential diagnosis of meningitis.