Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance
Recruitment status was Active, not recruiting
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Purpose
The primary purpose of this study is to apply state-of-the-art Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) techniques to measure changes over time in the brain.
| Condition | Intervention |
|---|---|
|
Memory |
Device: MRI |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | MRI and Decline of Aging Aviator Performance |
| Estimated Enrollment: | 100 |
| Study Start Date: | November 2002 |
| Estimated Study Completion Date: | December 2012 |
| Estimated Primary Completion Date: | December 2012 (Final data collection date for primary outcome measure) |
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Device: MRI
We expect that MRI and MRSI techniques will be a useful adjunct in research efforts to understand individual differences in performance of a complex attention-demanding task, such as flying a plane or driving a car. Other predictors of change in performance of a complex task may include simple tests of processing speed and working memory, past training and recent practice of the task, and genetic risk factors for degenerative brain disease. In this project, we will examine whether baseline MR measures are as useful as longitudinal MR measures in predicting amount of change over time in task performance.
This research is part of a long-term effort to achieve earlier identification of individuals at risk of decline and ultimately minimize loss of function.
Eligibility| Ages Eligible for Study: | 45 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
active healthy pilots
Inclusion Criteria:
- Subjects will be included if they have participated in the protocol "Age-Related Longitudinal Changes in Aviator Performance" and agree to participate in this protocol.
Exclusion Criteria:
- Subjects will be excluded if they currently have a major neurological disease, unstable/untreated medical disease (such as untreated hypertension).
- In consideration of the magnetic fields in which subjects will be placed for the MR scanning, we will also exclude subjects who are unable to safely and comfortably complete the scanning session. This includes individuals who are wearing any metal prosthesis or who have cardiac pacemakers or any other nonremovable metal objects.
- Subjects reporting a history of severe claustrophobia or poorly controlled back pain will be excluded because it is unlikely they could comfortably remain still in the MRI scanner for the duration of the scan.
- In addition, subjects who do not fit in the apparatus will also be excluded.
Contacts and Locations| United States, California | |
| VA Palo Alto Health Care System | |
| Palo Alto, California, United States, 94304 | |
| Principal Investigator: | Joy Taylor | Stanford University |
More Information
No publications provided
| Responsible Party: | Joy Taylor, Stanford University School of Medicine |
| ClinicalTrials.gov Identifier: | NCT01120860 History of Changes |
| Other Study ID Numbers: | SU-06302009-2941, 11097 |
| Study First Received: | May 7, 2010 |
| Last Updated: | June 9, 2011 |
| Health Authority: | United States: Institutional Review Board |
ClinicalTrials.gov processed this record on June 18, 2013