Genetic Biomarkers in Children With Neuroblastoma (Also Known as Neuroblastoma Epidemiology in North America [NENA])
Recruitment status was Not yet recruiting
RATIONALE: Studying the genes in a child's cancer cells may help doctors improve ways to diagnose and treat children with neuroblastoma.
PURPOSE: This clinical trial is studying the genes biomarkers in children with neuroblastoma.
Genetic: DNA analysis
Genetic: cytogenetic analysis
Genetic: polymerase chain reaction
Genetic: polymorphism analysis
Other: questionnaire administration
Other: study of socioeconomic and demographic variables
|Official Title:||Genetic Susceptibility Factors in the Etiology of Neuroblastoma (Also Known as Neuroblastoma Epidemiology in North America [NENA])|
- Correlation of genetic polymorphisms involved in folate, vitamin A, and related metabolic and transport pathways with the risk of neuroblastoma (NB) [ Designated as safety issue: No ]
- Joint effects of multiple genes on the risk of NB [ Designated as safety issue: No ]
- Effects of gene-exposure interactions on the risk of NB [ Designated as safety issue: No ]
- Genetic effects within specific NB subgroups [ Designated as safety issue: No ]
|Study Start Date:||February 2009|
|Estimated Primary Completion Date:||February 2012 (Final data collection date for primary outcome measure)|
- Evaluate the independent association of common genetic polymorphisms involved in folate, vitamin A, and related metabolic and transport pathways and the risk of neuroblastoma (NB) in children who were diagnosed before age 6.
- Evaluate the joint effects of multiple genes on the risk of NB.
- Evaluate the effects of gene-exposure interactions, with primary interest on folate, vitamin A, and choline intake, on the risk of NB.
- Evaluate genetic effects within NB subgroups defined by age at diagnosis and a Children's Oncology group classification schema based on age, MYCN oncogene status, histology, and DNA ploidy.
OUTLINE: This is a multicenter study.
The biologic mother of the patient is asked to complete a Diet History Questionnaire about diet during pregnancy, and information on demographics, lifestyle factors, medication used during pregnancy, history of breast feeding, and family history of cancer or birth defects.
Parents are given ORAgene saliva collection kits for self-collection. Saliva bio-specimen samples are collected from both biologic parents and the patient. Tissue samples previously stored in a tissue bank are obtained for deceased patients, if available. DNA is extracted from samples, amplified and analyzed using real-time PCR quantitation assay, and genotyped using single nucleotide polymorphisms.
|Study Chair:||Andrew F. Olshan, PhD||UNC Lineberger Comprehensive Cancer Center|