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Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

This study is currently recruiting participants.
Verified July 2011 by Imperial College London
Sponsor:
Information provided by:
Imperial College London
ClinicalTrials.gov Identifier:
NCT01118468
First received: May 5, 2010
Last updated: July 28, 2011
Last verified: July 2011
History of Changes
  Purpose

Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts "competes" with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.


Condition
Coronary Artery Bypass

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Imperial College London:

Estimated Enrollment: 40
Study Start Date: January 2010
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with previous bypass grafts undergoing angiography/ angioplasty who meet stduy criteria

Criteria

Inclusion Criteria:

  • Patients with previous coronary artery bypass grafts undergoing coronary angiography and graft restudy

Exclusion Criteria:

  • Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
  • Unable to consent
  • Contraindications to adenosine
  • Contraindications to cardiac MRI
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01118468

Contacts
Contact: Justin E Davies, MRCP, PhD 020 7594 33 86 justin.davies@imperial.ac.uk
Contact: Sayan Sen, MRCP 020 7594 33 86 sayan.sen@imperial.ac.uk

Locations
United Kingdom
Imperial College NHS Trust Recruiting
London, United Kingdom
Contact: Justin E Davies, MRCP, PhD     020 7594 33 86     justin.davies@imperial.ac.uk    
Contact: Sayan Sen     020 7594 33 86     sayan.sen@imperial.ac.uk    
Sponsors and Collaborators
Imperial College London
Investigators
Principal Investigator: Justin E Davies, MRCP PhD Imperial College London
  More Information

No publications provided

Responsible Party: Dr Justin E Davies, Imperial College London
ClinicalTrials.gov Identifier: NCT01118468     History of Changes
Other Study ID Numbers: 1426
Study First Received: May 5, 2010
Last Updated: July 28, 2011
Health Authority: United Kingdom: Research Ethics Committee

Keywords provided by Imperial College London:
Competitive Flow
Coronary artery bypass
Wave Intensity Analysis

ClinicalTrials.gov processed this record on May 16, 2013