Genetic Modifiers of Cystic Fibrosis Related Diabetes
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Purpose
This research is being done to find the genes and other factors that are responsible for differences among persons with cystic fibrosis. We are particularly interested in the factors that relate to the development of Cystic Fibrosis Related Diabetes (CFRD).
| Condition |
|---|
|
Cystic Fibrosis Related Diabetes |
| Study Type: | Observational |
| Study Design: | Observational Model: Family-Based Time Perspective: Prospective |
| Official Title: | Genetic Modifiers of Cystic Fibrosis Related Diabetes |
- Identification of Genes or other factors that influence the development of CFRD [ Time Frame: 5 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Blood will be drawn from study participants and their parents. Two tablespoons of blood (one tablespoon in small children) will be drawn by standard techniques from a vein in the arm. Whenever possible, blood samples for this study will be collected at the same time that it is done for medically needed blood tests. This blood will be used to extract DNA and to establish cell lines that we will store as a permanent source of DNA. We will compare your clinical symptoms with your DNA to see if additional genes that affect CF symptoms can be found. Some serum and plasma will be stored for later testing, as additional knowledge becomes available. Any tests done in the future with your stored blood samples or your DNA will only be to answer questions about genes for CF.
| Estimated Enrollment: | 1500 |
| Study Start Date: | April 2008 |
| Estimated Study Completion Date: | April 2015 |
Eligibility| Ages Eligible for Study: | 3 Months and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Individuals affected with Cystic Fibrosis and family members
Inclusion Criteria:
- Any person with Cystic Fibrosis and his/her parents.
Exclusion Criteria:
- None
Contacts and Locations| United States, Illinois | |
| Children's Memorial Hospital | Not yet recruiting |
| Chicago, Illinois, United States | |
| Contact: Susanna McColley, MD smccolley@northwestern.edu | |
| United States, Maryland | |
| Johns Hopkins Medicine | Recruiting |
| Baltimore, Maryland, United States, 21287 | |
| Contact: Scott M Blackman, MD, PhD 410-955-6463 sblackman@jhmi.edu | |
| Contact: Kathleen M Naughton, MS 443-287-5132 knaught1@jhmi.edu | |
| United States, Minnesota | |
| University of Minnesota | Not yet recruiting |
| Minneapolis, Minnesota, United States | |
| Contact: Antoinette Moran, MD moran001@tc.uminn.edu | |
| United States, Tennessee | |
| Vanderbilt University | Not yet recruiting |
| Nashville, Tennessee, United States | |
| Contact: Elizabeth Perkett, MD elizabeth.perkett@vanderbilt.edu | |
| Principal Investigator: | Scott M Blackman, MD, PhD | Johns Hopkins Medicine |
More Information
Publications:
| Responsible Party: | Scott M. Blackman, MD PhD Assistant Professor, Pediatrics, Johns Hopkins Medicine |
| ClinicalTrials.gov Identifier: | NCT01113216 History of Changes |
| Other Study ID Numbers: | CFF-CFRD01, K23DK083551 |
| Study First Received: | April 28, 2010 |
| Last Updated: | June 28, 2011 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Johns Hopkins University:
|
CF CFRD Diabetes Genetic Modifiers |
Additional relevant MeSH terms:
|
Cystic Fibrosis Diabetes Mellitus Fibrosis Pancreatic Diseases Digestive System Diseases Lung Diseases Respiratory Tract Diseases |
Genetic Diseases, Inborn Infant, Newborn, Diseases Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases Pathologic Processes |
ClinicalTrials.gov processed this record on June 18, 2013