Long Term Effect of General Practitioner Education on Antibiotic Prescribing (PAAIR2)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2010 by Henri Mondor University Hospital.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Henri Mondor University Hospital
ClinicalTrials.gov Identifier:
NCT01107223
First received: March 4, 2010
Last updated: April 19, 2010
Last verified: February 2010
  Purpose

Respiratory tract infections are the most common indication for antibiotic prescribing in primary care. Several studies have shown a strong relationship between antibiotic use and bacterial resistance. The aim of this trial was to assess the long-term effect of a continuous education program on general practitioners antibiotic prescribing behaviour. 170 physicians were included in this study. Physicians randomized in the education group attended a two days seminar focused on evidence-based guidelines on antibiotic use in respiratory tract infections. The intervention was limited at physicians level and did not target the patients.


Condition Intervention
Respiratory Tract Infections
Other: Experimental: Training to antibiotic prescription
Other: No education on antibiotic prescription rules.

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Health Services Research
Official Title: Long Term Effect of General Practitioner Education on Antibiotic Prescribing: a Large Scale Randomized Study

Resource links provided by NLM:


Further study details as provided by Henri Mondor University Hospital:

Primary Outcome Measures:
  • Change in the percentage of prescriptions containing an antibiotic between control and intervention groups (seminar on the treatment of respiratory tract infections). [ Time Frame: Effect of the intervention 4 to 6 months after the educational training. ] [ Designated as safety issue: No ]
    All prescriptions written by all general practitioners enrolled in the study were extracted each year from the French National Health System database. All data were compared to 2004 (baseline). Education group GPs attended a two-day seminar presenting evidence-based guidelines on antibiotic prescription in respiratory tract infections. The change (compared to baseline) in the percentage of prescriptions containing an antibiotic (antibiotic prescription rates) was compared between control and intervention groups.

  • Change in the cost of antibiotic prescription between control and intervention groups (seminar on the treatment of respiratory tract infections). [ Time Frame: Effect of the intervention 4 to 6 months after the educational training. ] [ Designated as safety issue: No ]
    All prescriptions written by all general practitioners enrolled in the study were extracted each year from the French National Health System database. All data were compared to 2004 (baseline). Education group GPs attended a two-day seminar presenting evidence-based guidelines on antibiotic prescription in respiratory tract infections. The change (compared to baseline) in the cost of antibiotic prescription was compared between control and intervention groups.


Secondary Outcome Measures:
  • Long term antibiotic prescription rates [ Time Frame: Effect of the intervention 28 to 30 months after the educational training. ] [ Designated as safety issue: No ]
    Long term change in the percentage of antibiotic prescriptions between both groups

  • Long term antibiotic cost. [ Time Frame: Effect of the intervention 28 to 30 months after the educational training. ] [ Designated as safety issue: No ]
    Long term change in the cost of antibiotic prescriptions between both groups

  • Symptomatic drug prescription rates [ Time Frame: Effect of the intervention 28 to 30 months after the educational training. ] [ Designated as safety issue: No ]
    Prescription rates of symptomatic drug for respiratory infections between both groups

  • Symptomatic drug cost. [ Time Frame: Effect of the intervention 28 to 30 months after the educational training. ] [ Designated as safety issue: No ]
    Cost of symptomatic drug between both groups

  • Effect of patient age. [ Time Frame: Effect of the intervention 28 to 30 months after the educational training. ] [ Designated as safety issue: No ]
    Effect of patient age on antibiotic prescription between both groups

  • Effect of a seminar on problem-solving strategy on prescriptions. [ Time Frame: Effect of the intervention 28 to 30 months after the educational training. ] [ Designated as safety issue: No ]
    A second randomization was performed among the intervention group. In one subgroup, GPs attended an additional seminar on problem-solving strategies. Antibiotic prescription rates were compared between controls, evidence-based and problem-solving subgroups. Antibiotic cost was also compared between the both subgroups


Enrollment: 170
Study Start Date: September 2004
Estimated Study Completion Date: April 2010
Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Training to antibiotic prescription
Physicians randomized in the education group attended a two days seminar focussed on evidence-based guidelines on antibiotic use in respiratory tract infections.
Other: Experimental: Training to antibiotic prescription
GPs assigned to the intervention group attended a two days didactic educational meeting on evidence-based guidelines for diagnosis and treatment of acute respiratory tract infection.
Placebo Comparator: control Other: No education on antibiotic prescription rules.
GPs assigned to control group received no specific recommendations on antibiotic prescription.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • General practitioners practicing in three departments of the Parisian area in France
  • General practitioners attending a two days didactic educational meeting on evidence-based guidelines for diagnosis and treatment of acute respiratory tract infection.

Exclusion Criteria:

  • None
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01107223

Locations
France
Henri Mondor Hospital, department of general practice
Créteil, France, 94000
Sponsors and Collaborators
Henri Mondor University Hospital
Investigators
Principal Investigator: Clause Attali, MD Henri Mondor University Hospital
  More Information

No publications provided

Responsible Party: Pr Claude Attali, Henri Mondor University Hospital, department of General Practice
ClinicalTrials.gov Identifier: NCT01107223     History of Changes
Other Study ID Numbers: PAAIR2
Study First Received: March 4, 2010
Last Updated: April 19, 2010
Health Authority: France: Institutional Ethical Committee

Keywords provided by Henri Mondor University Hospital:
Antibiotic
Prescribing behaviour
Guidelines
Respiratory tract infections
Non-antibiotic prescription

Additional relevant MeSH terms:
Respiratory Tract Infections
Infection
Respiratory Tract Diseases
Anti-Bacterial Agents
Antibiotics, Antitubercular
Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions
Antitubercular Agents

ClinicalTrials.gov processed this record on April 17, 2014