Genetics of Motor Learning

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2014 by National Institutes of Health Clinical Center (CC)
Information provided by:
National Institutes of Health Clinical Center (CC) Identifier:
First received: April 16, 2010
Last updated: March 14, 2014
Last verified: February 2014


- New studies in human genetics have revealed information about genetic connections to memory and motor behavior. Researchers are interested in investigating the role of genetics in motor learning, in conjunction with related studies taking place in the Human Motor Control Section of the National Institute of Neurological Diseases and Stroke (NINDS). Participants in motor learning studies conducted at NINDS will be asked to provide blood samples for further evaluation.


- To create a repository of blood samples from patients and healthy subjects who are participating in NINDS motor learning studies.


- Individuals between 18 and 100 years of age who are or will be participating in motor learning research studies at the National Institutes of Health.


  • Blood draws for genetic testing will usually be done on the same day as the motor learning study. Participants will provide one blood sample for research.
  • No treatment will be provided under this study.

Parkinson s Disease
Dystonic Disorders
Focal Dystonia
Movement Disorders

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Genetics of Motor Learning

Resource links provided by NLM:

Further study details as provided by National Institutes of Health Clinical Center (CC):

Primary Outcome Measures:
  • Genetic polymorphism frequency (e.g. BNDF Va166Met) compared to measures of motor learning (e.g. reaction time or fMRI BOLD signal change)

Estimated Enrollment: 1000
Study Start Date: April 2010
Detailed Description:


The objective of this study is to create a bio-repository of blood samples from patients and healthy subjects who are participating in NINDS motor learning studies. Blood will be analyzed for BDNF and samples stored for future genetic studies. . A variety of genes that may affect motor learning are being increasingly identified, and variations among these genes, referred to as polymorphisms, may help explain individual differences.


We will enroll up to five hundred healthy volunteers and five hundred volunteers with movement difficulties who are between the ages of 18 and 100 and who are already participating, or will be participating, in other protocols dealing with motor learning research studies at the National Institutes of Health (NIH).


This is an observational and repository protocol that involves a single blood sample for genetic analysis. This will allow the genetic characterization of subjects participating in motor learning protocols to be analyzed and tested for the role of genetics in motor learning results.


We will compare genetic variations with the different behavioral, electrophysiologic, imaging, or other outcomes acquired in the associated motor learning studies. Thus, we will determine whether specific polymorphisms are associated with different measures of motor learning.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

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Anyone aged 18-100 years and participating in a motor learning study at NIH is eligible to participate in this study.

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Anyone with impaired decisional capacity, inability to provide informed consent, or who is unable to safely give blood is not eligible to participate in this study.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01105845

Contact: Elaine P Considine, R.N. (301) 435-8518
Contact: Mark Hallett, M.D. (301) 496-9526

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)    800-411-1222 ext TTY8664111010   
Sponsors and Collaborators
Principal Investigator: Mark Hallett, M.D. National Institute of Neurological Disorders and Stroke (NINDS)
  More Information

Additional Information:
Publications: Identifier: NCT01105845     History of Changes
Other Study ID Numbers: 100092, 10-N-0092
Study First Received: April 16, 2010
Last Updated: March 14, 2014
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Motor Learning
Genetic Analysis
Parkinson Disease
Movement Disorders
Healthy Volunteer

Additional relevant MeSH terms:
Movement Disorders
Dystonic Disorders
Parkinson Disease
Nervous System Diseases
Central Nervous System Diseases
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Neurodegenerative Diseases
Neurologic Manifestations
Signs and Symptoms
Pathologic Processes processed this record on October 19, 2014