Non Invasive Imaging of Abdominal Aorta Aneurysm Hemodynamics and Wall Structure
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Purpose
The development of the abdominal aorta aneurysm is multifactorial. Through use of magnetic resonance imaging without contrast, this study will look closely at flow, the stresses hereby induced, as well as signs of inflammation in the vessel wall.
| Condition |
|---|
|
Aortic Aneurysm, Abdominal |
| Study Type: | Observational |
| Study Design: | Time Perspective: Cross-Sectional |
| Official Title: | Non Invasive in Vivo Evaluation of Abdominal Aorta Aneurysm Hemodynamics, Wall Stress, and Inflammation Using Magnetic Resonance Imaging |
| Estimated Enrollment: | 20 |
| Study Start Date: | March 2010 |
| Estimated Study Completion Date: | March 2012 |
| Estimated Primary Completion Date: | March 2012 (Final data collection date for primary outcome measure) |
The etiology of the abdominal aorta aneurysm is complex and multi-factorial. Biomechanic and hemodynamic stress contributes to aneurysmal growth, and the relevance of inflammation is gaining in terms of pathological influence. The technical advances of imaging now enable one to utilize magnetic resonance in reconstructing aortal blood flow. Newer post-imaging software then enables one to perform complex data analysis, wherein shear and wall-stress can be calculated. The goal of this study is to analyze the aneurysms of twenty patients. Values will be obtained for shear and wall stress. Additionally, the utilization of short tau wave inversion recovery (STIR) sequences will be performed to evaluate the presence or absence of acute edema and inflammation of the region. It should also be noted that particular attention will be placed on the so-called "neck" of the aneurysm, where the aneurysm typically tapers into what is often regarded as normal aortic tissue. This region is important for both the placement of a surgical bypass prosthesis or a deployed stent graft.
Eligibility| Ages Eligible for Study: | 20 Years to 90 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Twenty patients diagnosed with an infrarenal abdominal aorta aneurysm will be selected from our clinical database.
Inclusion Criteria:
- Infrarenal abdominal aorta aneurysm (AAA)
Exclusion Criteria:
- Lack of signed, informed consent
- Pacemaker or other implanted metal prostheses
- Claustrophobia
- Dementia
- Diabetes Mellitus
- Thoracoabdominal aorta aneurysm, per Crawford/Safi criteria
- Ehlers-Danlos, Marfans, or other diagnosed connective tissue disease
Contacts and Locations| Contact: Jacob W Budtz-Lilly, MD | (45) 28147705 | jacoblilly99@yahoo.dk |
| Contact: William Paaske, Professor | (45) 89496990 |
| Denmark | |
| Aarhus University, Skejby Hospital, Department of cardiothoracic and vascular surgery & MR-center | Recruiting |
| Aarhus, Denmark, 8000 | |
| Contact (45) 89496990 | |
| Principal Investigator: | Jacob W Budtz-Lilly, MD | Aarhus University Hospital Skejby, Department of cardiothoracic and vascular surgery |
More Information
No publications provided
| Responsible Party: | Nikolaj Eldrup, Counsultant MD PhD, Aarhus University Hospital |
| ClinicalTrials.gov Identifier: | NCT01104688 History of Changes |
| Other Study ID Numbers: | M-20100008 |
| Study First Received: | April 14, 2010 |
| Last Updated: | January 18, 2012 |
| Health Authority: | Denmark: The Regional Committee on Biomedical Research Ethics |
Keywords provided by Aarhus University Hospital:
|
Abdominal Aortic Aneurysm Wall Stress Shear Stress Inflammation Magnetic Resonance Imaging |
Additional relevant MeSH terms:
|
Aneurysm Aortic Aneurysm Inflammation Aortic Aneurysm, Abdominal |
Vascular Diseases Cardiovascular Diseases Aortic Diseases Pathologic Processes |
ClinicalTrials.gov processed this record on May 21, 2013