Exercise to Improve Outcomes of Treatment for Methamphetamine Users

Inclusion Criteria:

1. Be seeking treatment for their MA dependence;
2. Be 18 years of age or older, and 45 or younger for males, 55 or younger for females;
3. Meet DSM-IV-TR criteria for MA dependence;
4. Have vital signs that are within clinically acceptable normal range, e.g., resting pulse between 50 and 90 /min, blood pressures between 85-150mm Hg systolic and 45-90mm Hg diastolic;
5. Have a medical history and physical examination that, in the judgment of the study physician or Principal Investigator, show no clinically significant contraindications for study participation;
6. For females, provide negative pregnancy urine tests before randomization (and for the sub-sample, another negative test before the final PET scan at the conclusion of the intervention).

Exclusion Criteria:

1. Clinically significant heart disease or hypertension; unstable pulmonary or cardiovascular disease that would interfere with participation in exercise regimen
2. Neurological or psychiatric disorders as assessed by MINI or clinical interview, such as psychosis, bipolar illness, Tourette's syndrome, major depression, organic brain disease, dementia, or any other neuro-psychiatric disorder that would require ongoing treatment or that would make study compliance difficult;
3. Musculoskeletal disease that would prevent participation in exercise regimen
4. Baseline ECG showing evidence of cardiac ischemia, arrhythmia, or other clinically significant abnormalities
5. Untreated or unstable medical illness including: neuroendocrine, autoimmune, renal, hepatic, or active infectious disease (other than HIV) that requires immediate medical attention;
6. Clinically significant abnormalities in hematology and chemistry laboratory tests that may make participation hazardous;
7. Have HIV and unable to obtain a clearance for participation from his/her AIDS medical care provider;
8. Pregnant;
9. Any other illness, condition, or use of medications that, in the opinion of the PI and/or the study physician, would preclude safe participation or completion of the study.