Serum FGF-23 and Vitamin D Deficiency
We aimed to determine the effect of vitamin D replacement therapy on serum FGF-23 concentrations in vitamin D deficient women and to compare the FGF-23 concentrations of vitamin D deficient patients with healthy subjects and patients with genetically-determined hypophosphatemic rickets.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Effects Of Vitamin D Replacement Therapy on Serum FGF-23 Concentrations in Vitamin D Deficient Women In Short Term|
Vitamin D deficient females
(n =18, mean age 29.1±9.9 yrs)
vitamin D sufficient healthy females
(control group; n = 19, mean age 28.5±5.2 yrs)
genetically-determined hypophosphatemic rahitis
(n=13, mean age 26.5±15.1 yrs)
Study group was composed of vitamin D deficient females (n =18, mean age 29.1±9.9 yrs), vitamin D sufficient healthy females (control group; n = 19, mean age 28.5±5.2 yrs) and patients with genetically-determined hypophosphatemic rickets (n=13, mean age 26.5±15.1 yrs). Groups were compared for serum FGF-23, 1,25 dihydroxy vitamin D3, calcium, phosphate, bone turnover markers, intact parathyroid hormone and urinary excretion of calcium and phosphate. Vitamin D deficient group was re-evaluated after a standard treatment regimen.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01102751
|Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism|
|Istanbul, Turkey, 34390|