Early Incidence of Occupational Asthma Among Bakers, Pastry-makers and Hairdressers (ABCD)
Recruitment status was Recruiting
Background: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. Because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (OA) during the first years after inception of exposure. This study focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of OA in these "at risk" occupations according to exposure duration, and to identify risk factors of OA.
Methods: This study is a longitudinal retrospective study with a nested case-control to identify risk factors of OA. The assessment of incidence evolution is made by exploring a series of promotions (or retrospective cohorts) with increasing duration since at work. The study population is composed of subjects who graduated between 2001 and 2006 in sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure.
This study is a descriptive, monocentric, longitudinal and retrospective study with cross-sectional measurements.
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Evolution of the Incidence of Occupational Asthma at the Beginning of the Activity of Young Bakers, Pastry-makers and Hairdressers, and Exploration of Its Risk Factors|
- The early incidence of OA among young workers according to their sector of activity and exposure duration. [ Time Frame: 3-6 months after tle last inclusion ] [ Designated as safety issue: No ]
- The identification of risk factors of OA. [ Time Frame: 3-6 months after the last inclusion ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
whole blood, serum, plasma
|Study Start Date:||December 2008|
|Estimated Study Completion Date:||June 2010|
|Estimated Primary Completion Date:||June 2010 (Final data collection date for primary outcome measure)|
Exposed young workers graduated in sectors at risk of occupational asthma (bakery, pastry-making or hairdressing)
"Non-exposed" young workers graduated in sectors without specific occupational exposure as the sale or the food sectors.
|Contact: Thomas REMEN, PhD Studentfirstname.lastname@example.org|
|Contact: Christophe PARIS, MD/PhD||Christophe.Paris@nancy.inserm.fr|
|Nancy, France, 54000|
|Contact: Thomas REMEN, MSc email@example.com|
|Contact: Christophe PARIS, MD / PhD Christophe.Paris@nancy.inserm.fr|
|Principal Investigator: Christophe PARIS, MD / PhD|
|Principal Investigator: Denis ZMIROU-NAVIER, MD / PhD|
|Sub-Investigator: Stéphanie DOVI-ACOUETEY, MSc|
|Sub-Investigator: Thomas REMEN, MSc|
|Principal Investigator:||Christophe PARIS, MD / PhD||CHU Nancy, INSERM, Nancy University|
|Principal Investigator:||Denis ZMIROU-NAVIER, MD / PhD||INSERM, Nancy university, EHESP School of Public Health|