Effect of Colostrum on Gut Permeability and Endotoxin Level in Chronic Alcoholic Disease
Recruitment status was Recruiting
Chronic alcohol ingestion is related with leaky gut syndrome. Colostrum is well-studied that it has a effect of decreasing the degree of leaky gut syndrome.
So the investigators are planning to find out whether Colostrum has a effect of decreasing the degree of leaky gut syndrome.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
|Official Title:||Effect of Colostrum Administration on Improving Gut Permeability and Serum Endotoxin Level in Chronic Alcohol Drinkers With Hepatic Dysfunction|
- endotoxin [ Time Frame: 1st visit and 3 weeks after 1st visit ] [ Designated as safety issue: Yes ]
- lactulose/mannitol ratio [ Time Frame: 3 weeks ] [ Designated as safety issue: Yes ]
|Study Start Date:||March 2010|
|Estimated Study Completion Date:||December 2010|
|Estimated Primary Completion Date:||September 2010 (Final data collection date for primary outcome measure)|
|Placebo Comparator: Colostrum||
Dietary Supplement: colostrum
colostrum, 2g, 2 times a day, for 3 weeks
Other Name: Mucoba
|No Intervention: Sugar pill|
We randomly sort the participant as placebo group and colostrum group. Each group consists of 17 people. and the duration of our study for one participant is 3 weeks. (Participant takes colostrum for 3 weeks.)
When a person gets leaky gut syndrome, his or her endotoxin and lactulose/mannitol ratio (L/M ratio, in urine) can elevate.
So We will compare the value of those two parameters and LFT. etc. after the administration of colostrum or placebo.
|Contact: Jae Yong Shim, Masteremail@example.com|
|Contact: Hong Bae Kim, Bachelor||82-02-584-2823|
|Korea, Republic of|
|Gangnam Severance Hospital : Family medicine department||Recruiting|
|Seoul, Korea, Republic of|
|Contact: Jae Yong Shim, Master 82-02-2019-3155 firstname.lastname@example.org|
|Contact: Hong Bae Kim, Bachelor 82-02-584-2823|
|Sub-Investigator: Hong Bae Kim, Bacholer|
|Study Director:||Jae Yong Shim, Master||Gangnam Severance Hospital|