Genetics of Obesity in Chinese Youngs (GOCY)

This study is currently recruiting participants. (see Contacts and Locations)
Verified July 2013 by Shanghai Jiao Tong University School of Medicine
Sponsor:
Information provided by (Responsible Party):
Guang Ning, Shanghai Jiao Tong University School of Medicine
ClinicalTrials.gov Identifier:
NCT01084967
First received: March 10, 2010
Last updated: July 21, 2013
Last verified: July 2013
  Purpose

The purpose of this study is to explore the pathogenesis and genetic susceptibility of obese subjects,providing a convincing argument for further treatment of obesity and metabolic syndrome.


Condition
Obesity
Metabolic Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Study of Clinical Characteristics and Genetic Susceptibility in Chinese Obese Youngs

Resource links provided by NLM:


Further study details as provided by Shanghai Jiao Tong University School of Medicine:

Biospecimen Retention:   Samples With DNA

Whole blood,fasting serum and morning urine


Estimated Enrollment: 2000
Study Start Date: March 2009
Estimated Study Completion Date: September 2013
Estimated Primary Completion Date: September 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
Healthy lean control group
BMI:18.5-22.9kg/m2. Age:14-30 years old. To be proved normal by the examinations of liver and kidney function,blood lipids profile,fasting and postprandial plasma glucose, fasting insulin and HbA1c.
obesity group with BMI ≥30
obesity group 1000, lean healthy control group 1000

Detailed Description:

Obesity has become a major worldwide challenge to public health, owing to an interaction between the obesogenic environment and a strong genetic contribution.Previous studies found that genetic factors determine 40%-70% of obese phenotype.Under such circumstances, the screening of obesity susceptibility gene is particularly important for society or family to take measures to prevent obesity.

Recent extensive genome-wide association studies(GWASs) have identified numerous single nucleotide polymorphisms associated with obesity,but these loci together account for only a small fraction of the known heritable component.Two studies in 2010 Nature,for the first time, put rare copy number variation (CNV)in association with severe early-onset obesity.Their significance lie not only in the discovery of the pathogenic genes of severe early-onset obesity but,more importantly,in providing new strategies for finding out genes that cause complex diseases.

Obese patients and healthy lean controls proved by a series of blood biochemical examinations will be enrolled in this study.The present study intends to use the techniques such as enzyme-linked immunosorbent assay, real-time fluorescence quantitative PCR,gene chip,construction of viral vectors,transfection,taking advantage of the established database,by means of serum assays and functional tests, associate copy number variation with obesity phenotype to explain the root cause of obesity.Meanwhile biomarkers and genetic risk factors will be evaluated in the study subjects.

  Eligibility

Ages Eligible for Study:   14 Years to 30 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

The population from which cohorts will be selected include students, residents, staff, and/or faculty who are present on Shanghai Jiaotong University school of medicine, and surrounding areas.

Criteria

Inclusion Criteria:

  • body mass index (BMI)≥ 30kg/m2
  • predominantly east China to minimize population stratification
  • willing and able to provide informed consent

Exclusion Criteria:

  • pregnancy/lactation
  • Cushing syndrome
  • Hypothyroidism
  • obesity caused by pituitary and hypothalamic lesions
  • drug related obesity
  • history of major psychiatric illness
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01084967

Contacts
Contact: Guang Ning, MD.PhD 86-21-64370045 ext 665340 guangning@medmail.com.cn
Contact: Jie Hong, PhD 86-21-64370045 ext 665345 hongjie13d@hotmail.com

Locations
China, Shanghai
Shanghai Jiao Tong University School of Medicine Recruiting
Shanghai, Shanghai, China, 200025
Contact: Guang Ning, MD.PhD    86-21-64370045 ext 665340    guangning@medmail.com.cn   
Contact: Jie Hong, PhD    86-21-64370045 ext 665345    hongjie13d@hotmail.com   
Principal Investigator: Guang Ning, MD.PhD         
Sponsors and Collaborators
Shanghai Jiao Tong University School of Medicine
Investigators
Principal Investigator: Guang Ning, MD.PhD Shanghai Jiao Tong University School of Medicine
  More Information

No publications provided

Responsible Party: Guang Ning, Director, Shanghai Jiao Tong University School of Medicine
ClinicalTrials.gov Identifier: NCT01084967     History of Changes
Other Study ID Numbers: CCEMD008
Study First Received: March 10, 2010
Last Updated: July 21, 2013
Health Authority: China: Ethics Committee

Keywords provided by Shanghai Jiao Tong University School of Medicine:
obesity
metabolic syndrome
genetic risk markers
copy number variation

Additional relevant MeSH terms:
Metabolic Syndrome X
Obesity
Syndrome
Body Weight
Disease
Glucose Metabolism Disorders
Hyperinsulinism
Insulin Resistance
Metabolic Diseases
Nutrition Disorders
Overnutrition
Overweight
Pathologic Processes
Signs and Symptoms

ClinicalTrials.gov processed this record on October 30, 2014