Congestive Heart Failure: Causes of Sudden Worsening

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2010 by University Hospital Hradec Kralove.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University Hospital Hradec Kralove
ClinicalTrials.gov Identifier:
NCT01081925
First received: March 4, 2010
Last updated: NA
Last verified: February 2010
History: No changes posted
  Purpose

The purpose of the study is to recognize main causes of acute decompensation of chronic congestive heart failure.


Condition
Congestive Heart Failure

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Congestive Heart Failure: Causes of Sudden Worsening

Resource links provided by NLM:


Further study details as provided by University Hospital Hradec Kralove:

Estimated Enrollment: 100
Study Start Date: February 2010
Estimated Study Completion Date: February 2012
Estimated Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
Congestive heart failure
Patients suffering from sudden worsening of congestive heart failure

Detailed Description:

Congestive heart failure (CHF) presents a very significant cause of morbidity and mortality. The prevalence of CHF is between 2 and 4% and rises with age (in 70- to 80-year-old people is between 10 and 20%). CHF is the cause of 5% of all acute hospital admissions and accounts for 2% of expenses on health. The most common causes of worsening of the chronic CHF are ischemia, arrhythmias, valvular dysfunction, systemic or pulmonary hypertension, volume overload or fluid retention, high output conditions (infection, anemia, thyrotoxicosis), drugs (NSAIDs, cyclo-oxygenase (COX) inhibitors, thiazolidinediones) and medication nonadherence. The goal of this study is to determine the proportion of various reasons of acute worsening of CHF, using commonly available methods including assessment of serum drug levels.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients suffering from sudden worsening of congestive heart failure, who are examined at the Emergency department or admitted to University Hospital

Criteria

Inclusion Criteria:

  • able to provide informed consent
  • aged 19 years or more
  • history of heart failure of at least one month
  • examined or hospitalized for acute dyspnea at rest or with minimal exertion
  • clinical signs of fluid overload defined as at least one of following:
  • rales
  • jugular venous distension
  • peripheral edema
  • pulmonary congestion on X-ray
  • NT-proBNP above 210 pmo/l

Exclusion Criteria:

  • none
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01081925

Contacts
Contact: Radek Pelouch, MD 00420495834740 pelouch@centrum.cz
Contact: Jiri Ceral, MD 00420495832652 ceral@seznam.cz

Locations
Czech Republic
University Hospital Hradec Kralove Recruiting
Hradec Kralove, Czech Republic, 50005
Principal Investigator: Radek Pelouch         
Sub-Investigator: Jiri Ceral, MD         
Sub-Investigator: Miroslav Solar, MD         
Sponsors and Collaborators
University Hospital Hradec Kralove
Investigators
Principal Investigator: Radek Pelouch, MD University Hospital Hradec Kralove
  More Information

No publications provided

Responsible Party: Pelouch Radek, MD, University Hospital Hradec Kralove
ClinicalTrials.gov Identifier: NCT01081925     History of Changes
Other Study ID Numbers: MSM0021620817-HKJC
Study First Received: March 4, 2010
Last Updated: March 4, 2010
Health Authority: Czech Republic: Ethics Committee

Keywords provided by University Hospital Hradec Kralove:
Congestive Heart Failure
Cardiac Failure

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on July 24, 2014