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Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT01079221
First received: March 2, 2010
Last updated: April 8, 2013
Last verified: April 2013
History of Changes
  Purpose

COPD patients have a reduced exercise tolerance due to a ventilatory limitation.

Several studies have shown altered skeletal muscle function. The investigator will study the physiological response to knee-extensor exercise in COPD patients.


Condition Intervention
Chronic Obstructive Pulmonary Disease
 Behavioral: High intensity knee-extensor training

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Peak power [ Time Frame: At inclusion and after 6 weeks of training ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Mitochondrial respiration, Vmax [ Time Frame: At inclusion and after 6 weeks of training ] [ Designated as safety issue: No ]

Enrollment: 12
Study Start Date: February 2009
Study Completion Date: December 2012
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Knee extensor exercise training
High intensity aerobic knee-extensor exercise training
 Behavioral: High intensity knee-extensor training
High intensity aerobic knee-extensor exercise training, 4x 3 minutes interval training at < 90 % of peak power, 3 days/week for 6 weeks

Detailed Description:

Reduced exercise tolerance is one of the hallmarks of COPD. The principal causes for exercise intolerance are ventilatory limitation leading to deconditioning and inactivity. However the weak correlation between exercise capacity and FEV1 implies that other factors than reduced pulmonary function contribute to this impairment as well. Several studies have found changes in skeletal muscle, with fibre shift, increased oxidative stress, increased inflammatory cytokines and impaired mitochondrial function, suggesting a lower limb dysfunction.

Numerous exercise studies in COPD patients have shown physiological and physiological benefits of training and endurance training is now regarded as an important part in pulmonary rehabilitation.

In this study we investigate training effects in patients with moderate to severe COPD with special focus on skeletal muscle.

COPD patients will perform high intensity aerobic interval knee-extensor exercise training 3 days/week for six weeks . At baseline and follow-up, muscle oxygen consumption and mitochondrial respiration will be measured.

  Eligibility

Ages Eligible for Study:   50 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • COPD diagnosis with FEV1<70% exp, FEV1%FVC <70 %
  • Age> 50 years

Exclusion Criteria:

  • Heart failure
  • Symptomatic coronary artery disease
  • Cancer
  • Alcohol and drug abuse
  • Severe mental illness
  • Lower respiratory illness
  • Participation in exercise- or lung rehabilitation program last 3 months
  • pregnancy
  • oral steroid use
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01079221

Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Study Director: Ulrik Wisløff, PhD prof. Norwegian University of Science and Technology
  More Information

No publications provided by Norwegian University of Science and Technology

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT01079221     History of Changes
Other Study ID Numbers: 42009297
Study First Received: March 2, 2010
Last Updated: April 8, 2013
Health Authority: Norway: Norwegian Social Science Data Services
Norway: Ministry of Health and Care Services
Norway:National Committee for Medical and Health Research Ethics

Keywords provided by Norwegian University of Science and Technology:
exercise
Knee extensor

Additional relevant MeSH terms:
Lung Diseases
Respiration Disorders
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on June 17, 2013