Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy
The purpose of this study is to examine changes in ventilation and airway pressures during conventional bronchoscopy of intubated patients.
Acute Respiratory Distress Syndrome
Acute Lung Injury (ALI)
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy Under Volume Controlled (VC) and Pressure Controlled (PC) Ventilation|
- Changes in ventilation, airway pressures and blood gases after bronchoscope insertion. [ Time Frame: 2 minutes after bronchoscope insertion/ mode change ] [ Designated as safety issue: Yes ]paO2, paCO2 (kPa), airway and ventilator pressures (cmH2O)
Biospecimen Retention: Samples Without DNA
Arterial blood gases
|Study Start Date:||March 2002|
|Study Completion Date:||April 2010|
|Primary Completion Date:||April 2010 (Final data collection date for primary outcome measure)|
|ARDS / ALI patients||
Airway pressures, ventilation changes and blood gas changes are recorded in a group of intubated patients on mechanical ventilation before and after bronchoscope insertion. The registration is done immediately before a therapeutic/diagnostic bronchoscopy requested by a staff physician not involved n the study.
Mechanically ventilated patients often need bronchoscopy as a diagnostic procedure or for visually directed elimination of secretions. Partial endotracheal tube occlusion by the bronchoscope increases airflow resistance. Inhibition of inspiratory flow may be compensated for by augmented inspiratory pressure. Reduced expiratory flow however, cannot be compensated for by most ventilators and could lead to higher airway - and intrathoracic pressures that are not detected by pressure transducers in the ventilator tubing. In this study we compare changes in ventilation, airway pressures, ventilator pressures and blood gases during bronchoscopy of intubated patients in both volume controlled and pressure controlled ventilation. Our hypothesis are that 1) increased resistance in the tube during bronchoscopy leads to high intrabronchial airway pressures when the ventilator is in volume controlled mode, and 2) when the ventilator is in pressure controlled mode, increased resistance in the tube during bronchoscopy leads to reduced Tidal Volume and moderately increased paCO2.
|Oslo University Hospital - Ulleval|
|Oslo, Norway, 0407|
|Study Director:||Helge Opdahl, MD, PhD||Oslo University Hospital - Ulleval, Norway|
|Study Director:||Ole H Skjønsberg, MD, PhD||Oslo University Hospital Ulleval|
|Study Director:||Fredrik Borchsenius, MD||Oslo University Hospital Ulleval|