Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification PROJET " MOMIC "

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2011 by Institut National de la Santé Et de la Recherche Médicale, France.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier:
NCT01075061
First received: February 4, 2010
Last updated: December 29, 2011
Last verified: December 2011
  Purpose

Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. The aim of this study is to unravel the pathophysiology of the CMM that remains poorly elucidated. The combination of imaging studies and neurophysiological studies using transcranial magnetic stimulation in a homogeneous and relatively large group of patient is likely to allow us to better understand the underlying pathophysiology of the disorder. Using a linkage analysis approach we will try to identify a locus associated with CMM and related candidate genes.


Condition Intervention
Healthy
Other: healthy volunteers
Other: Kallmann
Other: Congenital Mirror Movement

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification : MOMIC

Further study details as provided by Institut National de la Santé Et de la Recherche Médicale, France:

Primary Outcome Measures:
  • - To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM [ Time Frame: 08/2011 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • - To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis [ Time Frame: 08/2011 ] [ Designated as safety issue: No ]

Estimated Enrollment: 45
Study Start Date: February 2010
Estimated Study Completion Date: August 2012
Estimated Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
healthy volunteers
healthy volunteers
Other: healthy volunteers
morphological and functional brain MRI; transcranial magnetic stimulation
Kallmann
Kallmann syndrome patients
Other: Kallmann
morphological and functional brain MRI; transcranial magnetic stimulation
Congenital Mirror Movement
patients with CMM
Other: Congenital Mirror Movement
morphological and functional brain MRI; transcranial magnetic stimulation

  Eligibility

Ages Eligible for Study:   11 Years to 82 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patients aged from 11 to 82 years
  • Members of the family of interest displaying mirror movements or being obligatory asymptomatic carrier, without additional manifestation or malformation; or patient with genetically proven Kallmann syndrome and mirror movements.
  • No contraindication for MRI or TMS study

Exclusion Criteria:

  • inability to provide an informed consent
  • Simultaneous participation in another clinical trial
  • Treatment that modulate cortical excitability (for the TMS part of the study only)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01075061

Contacts
Contact: Emmanuel ROZE, MD 331 42 16 19 74 emmanuel.roze@psl.aphp.fr

Locations
France
Fédération des Maladies du Système Nerveux, Hôpital Pitié Salpétrière Recruiting
Paris, France, 75013
Contact: Emmanuel ROZE, MD    331 42 16 19 74    emmanuel.roze@psl.aphp.fr   
Sponsors and Collaborators
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
Principal Investigator: Emmanuel ROZE, MD Institut National de la Santé Et de la Recherche Médicale, France
  More Information

No publications provided

Responsible Party: Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier: NCT01075061     History of Changes
Other Study ID Numbers: C09-06
Study First Received: February 4, 2010
Last Updated: December 29, 2011
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Keywords provided by Institut National de la Santé Et de la Recherche Médicale, France:
Congenital mirror movement, physiopathology, imaging, transcranial magnetic stimulation, candidate gene

ClinicalTrials.gov processed this record on August 01, 2014