Exercise Training Effects in Patients With Heart Failure

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Serafim Nanas, University of Athens
ClinicalTrials.gov Identifier:
NCT01071629
First received: February 18, 2010
Last updated: January 17, 2013
Last verified: January 2013
  Purpose

Chronic heart failure (CHF) is a common syndrome characterized by several central hemodynamic and peripheral vascular and muscle abnormalities including autonomic imbalance, neuro-hormonal over-activation and decreased oxidative status.

In patients suffering from CHF, exercise confers several beneficial effects on the cardiovascular and peripheral systems, mainly by continuous aerobic training. However, interval aerobic training has also been validated as an alternate form of training that increases the exercise capacity of patients who are in CHF.

Recent studies have suggested that resistance training alone or as a complementary program besides the traditionally aerobic continuous training might exert favorable effects. However, little it is known about the combined effects of interval and strength training in CHF patients.

Aim of this prospective randomized controlled study was to investigate the effects of combined interval and strength training comparing to interval training alone in CHF patients.


Condition Intervention
Chronic Heart Failure
Other: Exercise training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Aerobic Interval Training Versus Combined Aerobic Interval Training and Strength Training Effects in Patients With Heart Failure

Resource links provided by NLM:


Further study details as provided by University of Athens:

Primary Outcome Measures:
  • Aerobic exercise capacity [ Time Frame: 3 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Endothelial function, oxygen kinetics, ventilatory drive [ Time Frame: 3 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 40
Study Start Date: November 2004
Estimated Study Completion Date: September 2013
Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Combined interval and strength training
CHF Pts randomly designed at the combined interval and strength training group
Other: Exercise training
Interval training (30 sec 50% of peak Work Rate achieved at the steep ramp test/60 sec recovery no exercise) for 20 min and Strength training of the quadriceps, hamstrings, muscles of the shoulder and biceps brachialis for 20 min 3 times per week for 36 sessions
Active Comparator: Aerobic interval training
CHF Patients that randomly designed to participate at the interval training group
Other: Exercise training
Interval training (30 sec 50% of peak Work Rate achieved at the steep ramp test/60 sec recovery no exercise) for 40 min in the interval training group

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Stable systolic heart failure
  • NYHA functional class ≤ III
  • Optimal medical treatment

Exclusion Criteria:

  • Contraindications for a maximal cardiopulmonary exercise testing (CPET) according to the American Thoracic Society/American College of Chest Physicians Statement
  • Moderate to severe COPD
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01071629

Locations
Greece
Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, First Critical Care Unit, School of Medicine, National & Kapodistrian University of Athens
Athens, Greece, 10676
Sponsors and Collaborators
University of Athens
Investigators
Principal Investigator: Serafim Nanas, MD University of Athens
  More Information

Publications:
Responsible Party: Serafim Nanas, MD, University of Athens
ClinicalTrials.gov Identifier: NCT01071629     History of Changes
Other Study ID Numbers: UOA-2010
Study First Received: February 18, 2010
Last Updated: January 17, 2013
Health Authority: Greece: Ethics Committee

Keywords provided by University of Athens:
interval training
strength training
exercise capacity
chronic heart failure
Cardiac rehabilitation

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on August 01, 2014