Transcranial Doppler Ultrasonography and Brain Death
In France the diagnosis of brain death relies on electroencephalography (EEG) or cerebral angiography. Concerning the latter a time of 6 hours is mandatory between the clinical diagnosis and the realization of the cerebral computed tomography (CT) angiography. Transcranial doppler (TCD) is not recommended in the french guidelines for the diagnosis of brain death. In other countries, some flow patterns allow to confirm the diagnosis of brain death. The hypothesis of our study is that TCD could shorten the time between the clinical diagnosis of brain death and the realization of the CT angiography.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Evaluation of Transcranial Doppler Ultrasonography to Guide the Time of Cerebral Angiography for the Brain Death Diagnosis|
- Time between clinical diagnosis of brain death and realization of CT angiography [ Time Frame: the outcome is assessed when the CT angiography is performed ] [ Designated as safety issue: No ]
- Number of CT angiography required for the diagnosis of brain death [ Time Frame: the outcome is measured until the diagnosis of brain death is confirmed ] [ Designated as safety issue: No ]
|Study Start Date:||February 2009|
|Study Completion Date:||June 2011|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
CT angiography is performed 6 hours after the clinical diagnosis of brain death.
When the diagnosis of brain death is made, TCD is performed and then every 2 hours until the flow patterns compatible with brain death are found. Then a CT angiography is performed.
Other: Transcranial doppler
A TCD is performed on all cerebral arteries (mean cerebral arteries, anterior cerebral arteries, basilar trunk, vertebral arteries and carotid arteries) until a flow pattern compatible with brain death is found
|Centre Hospitalier Universitaire de Nice|
|Nice, France, 06000|
|Principal Investigator:||Jean-Christophe Orban, MD||Nice University Hospital|