Efficacy and Akathisia Incidence of Slow Infusion Metoclopramide
The purpose of this study is to compare the effects of metoclopramide administration in bolus versus slow infusion medications in ED patients complaining of nausea for the determination of the therapeutic effect and prevention of akathisia.
This was a prospective, randomized, double-blind trial. The investigation was held between 01 March 2007 and 01 May 2008, in the Emergency Department of Pamukkale University Faculty of Medicine. The patients with moderate to severe nausea randomized and divided into two groups as for the previously planned administration type of drug. Ten mg metoclopramide was administered in one group with slow infusion (SIG) in 15 minutes, via 2 minutes bolus infusion (BIG) into the other group. Whole procedure was observed, akathisia and nausea scores and vital changes were recorded.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
- akathisia and nausea scores [ Designated as safety issue: Yes ]
|Study Start Date:||March 2007|
|Study Completion Date:||May 2008|
|Primary Completion Date:||March 2007 (Final data collection date for primary outcome measure)|
|Active Comparator: 2 minutes bolus infusion||Drug: metoclopramide 10 mg|
|Active Comparator: 15 minutes slow infusion||Drug: metoclopramide 10 mg|