Analysis of Proinflammatory Factors in the Synovial Fluid In Patients With Rotator Cuff Disease
Recruitment status was Not yet recruiting
Role of proinflammatory factors in Patients with Rotator Cuff Disease
To measure the levels of various cytokines and metalloproteases in patients with rotator cuff disease, and control group and to determine the correlations among them.
Rotator Cuff Disease
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
- cytokines and MMP's levels in patients with RC pathology and in control group [ Time Frame: 12 month ] [ Designated as safety issue: No ]
- Levels of pain curve by using Visual Analogue Scale [ Time Frame: 12 month ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Synovial fluid lavages will be collected at the time of arthroscopic RC reconstruction or other shoulder arthroscopy that will be performed for therapeutic goals (instability repair, SLAP lesion).
|Study Start Date:||March 2010|
|Estimated Study Completion Date:||March 2011|
|Estimated Primary Completion Date:||March 2011 (Final data collection date for primary outcome measure)|
This study will include a consecutive series of patients who met the study inclusion criteria. Study group patients will be diagnosed RC tear on clinical examination and imaging findings (US and MRI) that will be verified at arthroscopy in order to complete the enrollment.
Control group will include patients suffering from shoulder instability that scheduled for elective surgical repair.
We hypothesize that cytokines and MMP's level will be significantly higher in patients with RC pathology than in control group and will be related to the time frame since injury (i.e. - higher levels as close to the injury). In addition we will examine possible relation of those levels to the pain curve by using Visual Analogue Scale.