Exercise and Lung Cancer Trial

Inclusion Criteria:

1. Histologically confirmed early-stage non-small cell or small cell lung cancer who have undergone curative-intent complete surgical resection at Duke University Medical Center (DUMC)
2. At least 21 years old. Children are not diagnosed with lung cancer,
3. An interval of at least 6 months following surgical resection,
4. An interval of no longer than 24 months post-resection,
5. Ability to read and understand English,
6. Primary attending oncologist approval,
7. Sedentary (i.e., patients not performing regular exercise on at least 3 days a week, for at least 30 minutes each session, at a moderate or vigorous intensity for the past month),
8. Willingness to be randomized,
9. Signed informed consent prior to initiation of study-related procedures, and
10. Reside within driving distance of DUMC, as necessitated by the clinic-based assessments and supervised exercise training interventions.

Exclusion Criteria:

1. Presence of a concurrent, actively treated other malignancy or history of other malignancy treated within the past 3 years (other than non-melanoma skin cancer),
2. Presence of metastatic disease,
3. Scheduled to receive any form of adjuvant cancer therapy (i.e., radiation, chemotherapy, or any form of targeted therapy),
4. Pregnancy,

5. Subjects must not have any of following absolute contraindications to maximal exercise testing as recommended by the American Thoracic Society and exercise testing guidelines for cancer patients:

   1. acute myocardial infarction (3-5 days),
   2. unstable angina,
   3. uncontrolled arrhythmias causing symptoms or hemodynamic compromise,
   4. syncope,
   5. acute endocarditis,
   6. acute myocarditis or pericarditis,
   7. uncontrolled heart failure,
   8. acute pulmonary embolus or pulmonary infarction,
   9. thrombosis of lower extremities,
   10. suspected dissecting aneurysm,
   11. uncontrolled asthma,
   12. pulmonary edema,
   13. room air desaturation at rest ≤85%,
   14. respiratory failure,
   15. acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise,
   16. mental impairment leading to inability to cooperate, and
   17. extensive bone metastases.