Prognostic Value of Progesterone for In Vitro Fertilization (IVF) Outcome (PROG2)
This observational study attempts to investigate the potential role of serum progesterone levels on the day of hCG administration (thus, the end of the follicular phase) on the probability of pregnancy, in patients undergoing IVF with the use of GnRH antagonists and recombinant gonadotrophins.
There has been evidence, that increased serum levels of progesterone are associated with a decreased probability of pregnancy after IVF.
This study will attempt to explore the role of progesterone on the outcome of IVF, by closely monitoring its levels during the late follicular phase.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Effect of Serum Progesterone Levels on the Day of hCG Administration on the Probability of Pregnancy in Patients Treated by IVF Using GnRH Antagonists and Recombinant Gonadotrophins|
- Clinical pregnancy, defined as ultrasound evidence of fetal heart activity at 6-8 weeks of gestation [ Time Frame: At 6-8 weeks of gestation ] [ Designated as safety issue: No ]
- Pregnancy (defined as a b-hCG> 25 IU/L) [ Time Frame: 12 days after embryo transfer ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
6ml of serum will be frozen and stored for later analysis
|Study Start Date:||May 2009|
|Study Completion Date:||June 2013|
|Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
|Patients undergoing IVF with rFSH and GnRH antagonists|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01067664
|Unit for Human Reproduction, 1st Dept. of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki|
|Principal Investigator:||Basil C Tarlatzis, MD, PhD||1st Dept. of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki|
|Principal Investigator:||Christos A Venetis, MD, MSc||Unit for Human Reproduction, 1st Dept. of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki|