The Role of Serum Leptin Levels in Multiple Sclerosis Disease Activity While on Interferon Beta 1a (Rebif) Treatment
To determine a correlation between serum leptin levels, nitric oxide preceding a relapse and change in leptin and nitric oxide levels during exacerbation in relapsing remitting multiple sclerosis patients.
|Study Design:||Observational Model: Case-Crossover
Time Perspective: Prospective
|Official Title:||The Role of Leptin Levels in Multiple Sclerosis|
- Fasting leptin and nitric oxide testing [ Time Frame: monthly, for 12 months ] [ Designated as safety issue: No ]
|Study Start Date:||December 2009|
|Study Completion Date:||July 2011|
This is an observational pilot study in patients with definitive relapsing-remitting multiple sclerosis to determine whether there is a correlation in serum leptin levels and serum nitric oxide levels during a clinically observed increase in disease activity. Each subject will followed for 12 months while taking interferon beta-1a subcutaneous injections 3 times a week.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01067573
|United States, Florida|
|Tampa, Florida, United States, 33612|
|Principal Investigator:||Stanley J Krolczyk, DO, RPH||University of South Florida|