Malaria Survey in Mbarara District, Uganda 2010

This study has been completed.
Sponsor:
Collaborator:
Medecins Sans Frontieres
Information provided by:
Epicentre
ClinicalTrials.gov Identifier:
NCT01062386
First received: February 3, 2010
Last updated: August 11, 2011
Last verified: August 2011
  Purpose

Malaria is one of the major public health problems in Sub-Saharan Africa. In response to this threat, Roll Back Malaria (RBM) has rolled back a strategy using ACT as first line therapy for malaria episode, a wide distribution of Insecticide Treated Bednet (ITN), intermittent presumptive treatment of pregnant women and indoor residual spraying. Recent epidemiological observations suggested a decline in malaria prevalence in some countries but further evidences are still needed to confirm this evolution. The RBM strategy requires the use of reliable rapid diagnostic test (RDT) for which an operational assessment is necessary. Lastly, home-based management of malaria is also an important compound of this strategy. However, a better understanding of the actual use of antimalarial drugs, of the use of bednet and of the barrier to the use of health care is important to implement good quality strategies for malaria control.

This study is a cross-sectional community based survey made of two rounds (one in January 2010 and the second in June 2010). The general objective is to measure the prevalence of infection with Plasmodium falciparum at two periods of the year (at the moment of lowest and highest transmission based on the seasonal rainfalls) and to compare it with the prevalence estimated in 2004 after the rainy season for the same area. Specific objective are the estimation of the prevalence by age stratum, the analysis of the geographical distribution of the infection, the description of the parasitological characteristics, the assessment of three RDT, the description and the analysis of the prevention and care seek behaviours related to malaria.

The study area is the great Mbarara district located in south-west of Uganda. A three-stage cluster sampling method will be used. Spatial information will be collected with global positioning system and imported to Geographical Information System. Behaviour information will be collected through face to face interview.


Condition
Malaria

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: The Epidemiology of Malaria Among Children Under Five in Mbarara District, Uganda - A Cross-sectional Population-based Survey 2010

Resource links provided by NLM:


Further study details as provided by Epicentre:

Primary Outcome Measures:
  • Proportion of malaria infections in children under 5 years of age [ Time Frame: January-February 2010 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Proportion of families with knowledge, attitude and practice regarding malaria prevention [ Time Frame: January-February 2010 ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Blood sample for:

Malaria rapid diagnostic test, Malaria Blood smear, Malaria PCR, Anopheles mosquitoes anti-saliva antibodies


Enrollment: 2320
Study Start Date: January 2010
Study Completion Date: July 2010
Primary Completion Date: February 2010 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   1 Month to 59 Months
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Children living in Great Mbarara district

Criteria

Inclusion Criteria:

  • Males and females
  • Ages 1 month to 59 months

Exclusion Criteria:

  • None
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01062386

Locations
Uganda
Greater Mbarara district
Mbarara, Uganda
Sponsors and Collaborators
Epicentre
Medecins Sans Frontieres
Investigators
Principal Investigator: Carolyn Nabasumba Epicentre
  More Information

No publications provided

Responsible Party: Carolyn Nabasumba, Epicentre
ClinicalTrials.gov Identifier: NCT01062386     History of Changes
Other Study ID Numbers: Epicentre/Mba/2010/MalPrev
Study First Received: February 3, 2010
Last Updated: August 11, 2011
Health Authority: Uganda: Research Ethics Committee

Keywords provided by Epicentre:
prevalence
transmission
knowledge
attitude
practice

Additional relevant MeSH terms:
Malaria
Protozoan Infections
Parasitic Diseases

ClinicalTrials.gov processed this record on July 26, 2014