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Glycemic Index and Polyphenol Bioavailability of Potatoes (GI)

This study has been completed.
Sponsor:
Collaborator:
Nutrasource Diagnostics Inc.
Information provided by:
Guelph Food Research Centre
ClinicalTrials.gov Identifier:
NCT01053793
First received: January 20, 2010
Last updated: January 14, 2011
Last verified: January 2011
  Purpose

The purpose of this study is to determine the glycemic index of four varieties of potatoes and to determine the bioavailability of polyphenols contained in these potatoes.


Condition Intervention
Diabetes
Insulin Resistance
Other: Glycemic response to different varieties of potatoes

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Bio-availability Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: A Trial to Measure the Glycemic Index and Polyphenol Bioavailability of Four Different Varieties of Potato.

Resource links provided by NLM:


Further study details as provided by Guelph Food Research Centre:

Primary Outcome Measures:
  • Glycemic response [ Time Frame: 2 hrs ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Bioavailability of polyphenols from potatoes [ Time Frame: 4 hours ] [ Designated as safety issue: No ]

Estimated Enrollment: 10
Study Start Date: January 2010
Study Completion Date: March 2010
Primary Completion Date: February 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Glucose Standard Other: Glycemic response to different varieties of potatoes
the glycemic response top 50g available carbohydrates from 4 potato varieties will be compared to a 50g glucose standard
Other Names:
  • Purple potato
  • Red potato
  • White potato
  • Yellow potaot
Experimental: Potato Variety Other: Glycemic response to different varieties of potatoes
the glycemic response top 50g available carbohydrates from 4 potato varieties will be compared to a 50g glucose standard
Other Names:
  • Purple potato
  • Red potato
  • White potato
  • Yellow potaot

Detailed Description:

Ten healthy persons will have a fasting blood sample drawn and asked to randomly consume a 50g glucose drink (2 occasions), or 50g carbohydrate equivalent of cooked purple, red, yellow and white potatoes. Further blood samples will be obtained at 15,30, 45, 60, 90, 120, 180, 240 mins. Bloods from the first 2 hours will be analyzed for glucose and insulin to determine the glycemic response. Hourly blood samples will be analyzed for polyphenol to determine the bioavailability of polyphenols from the different potato variety. Urine samples will be collected before ingestion of the food items and again at 4 hours, and will be used to determine polyphenol bioavailability.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy, non-smoker on no medication
  • normal glucose tolerance
  • willing to have a catheter inserted in forearm

Exclusion Criteria:

  • abnormal glucose tolerance
  • abnormal BMI
  • on medication for a chronic disorder
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01053793

Locations
Canada, Ontario
Nutrasource Diagnostic Inc
Guelph, Ontario, Canada, N1G 0B4
Sponsors and Collaborators
Guelph Food Research Centre
Nutrasource Diagnostics Inc.
Investigators
Principal Investigator: Dan Ramdath, PhD Agriculture and Agri-Food Canada
Study Director: Maggie Laidlaw, PhD Nutracource Diagnostics Inc
  More Information

Publications:
Responsible Party: Dr. Dan Ramdath - Research Scientist, Agriculture and Agri-Food Canada - Guelph Food Research Centre
ClinicalTrials.gov Identifier: NCT01053793     History of Changes
Other Study ID Numbers: 09-11-004, GFRC 09-11-004
Study First Received: January 20, 2010
Last Updated: January 14, 2011
Health Authority: Canada: Canadian Institutes of Health Research

Keywords provided by Guelph Food Research Centre:
Glycemic index
Anthocyanin
Potato
Polyphenol

Additional relevant MeSH terms:
Insulin Resistance
Glucose Metabolism Disorders
Hyperinsulinism
Metabolic Diseases

ClinicalTrials.gov processed this record on November 27, 2014