The Relation Between Dedicated Extremity MRI Synovitis and Structural Deterioration Radiographic in Patients With Rheumatoid Arthritis in Clinical Remission. Preliminary Study
Recruitment status was Recruiting
The major aim of treatment for rheumatoid arthritis is remission. Nevertheless, structural radiographic progression is observed in 15 to 20% of patient getting remission. Numerous definitions of the remission proposed by literature remain imperfect.
Recently ultrasonography and MRI seem to be helpful in diagnosis and follow-up of rheumatoid arthritis.
Studies in patients with clinical remission are reporting 75 to 90% of persistent MRI and ultrasonography synovitis, 45% of cases with synovial activity.
To our knowledge, in such case few studies showed correlation between persistent imaging synovitis and structural radiographic progression.
On the other hand, no studies with extremity dedicated RMI in patients with remission are reported.
In this preliminary study, the investigators propose to evaluate in patients with rheumatoid arthritis remission and persistent dedicated MRI synovitis the structural radiographic progression at one year.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Screening
|Official Title:||The Relation Between Dedicated Extremity MRI Synovitis and Structural Deterioration Radiographic in Patients With Rheumatoid Arthritis in Clinical Remission.Preliminary Study|
- Dedicated extremity MRI (hand and wrist)/ X-Ray (hand, wrist and foot) [ Time Frame: at Month 0 (first visit) and Month 12 (last visit) ] [ Designated as safety issue: No ]
- Ultrasonography (hand, wrist and foot) [ Time Frame: at Month 0 (first vist) and Month 12 (last visit) ] [ Designated as safety issue: No ]
|Study Start Date:||April 2010|
|Estimated Study Completion Date:||April 2012|
|Primary Completion Date:||April 2010 (Final data collection date for primary outcome measure)|
Dedicated extremity MRI
Structural deterioration radiographic assessed by dedicated extremity MRI
dedicated extremity MRI
Please refer to this study by its ClinicalTrials.gov identifier: NCT01050010
|Contact: Christine ALBERT-SABONNADIERE, PhDfirstname.lastname@example.org|
|Rheumatology Department, Nice University Hospital||Not yet recruiting|
|Nice, France, 06000|
|Contact: Christine ALBERT-SABONNADIERE, PhD email@example.com|
|CHU de NICE||Recruiting|
|Nice, France, 06000|
|Contact: Christine ALBERT-SABONNADIERE, M.D. 0492035481|
|Principal Investigator: Christine ALBERT-SABONNADIERE, M.D.|
|Principal Investigator:||Christine ALBERT-SABONNADIERE, PhD||Nice University Hospital|