Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

Ansgar Berg, Haukeland University Hospital

ClinicalTrials.gov Identifier:

NCT01044979

First received: December 17, 2009

Last updated: December 17, 2012

Last verified: December 2012

History of Changes

Purpose

The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.

Condition
Colloid Osmotic Pressure

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma, a Methodological Study

Further study details as provided by Haukeland University Hospital:

Biospecimen Retention: Samples Without DNA

Serum and interstitial fluid

Enrollment:	50
Study Start Date:	December 2009
Study Completion Date:	September 2010
Primary Completion Date:	September 2010 (Final data collection date for primary outcome measure)

Detailed Description:

Fluid loss from circulating plasma volume is one of the contributors of oedema formation. Measurement of colloid osmotic pressure (COP) both in plasma and in interstitial fluid can be utilised in planing of fluid therapy in patients with oedema. Different methods of sampling interstitial fluid are well validated in animal models, but not in human. Sampling of interstitial fluid by subcutaneous sewn wicks is a well-known method and can be painful. Local anaesthetics can reduce pain. By comparing interstitial fluid taken from areas with or without application of local anaesthetics, a possible influence in COP values can be detected.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Healthy volunteers over 18 years.

Criteria

Inclusion Criteria:

Adults over 18 years

Exclusion Criteria:

Ongoing illness
Medication

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01044979

Locations

Norway
Haukeland University Hospital
Bergen, Norway, 5021

Sponsors and Collaborators

Haukeland University Hospital

Investigators

Principal Investigator:

Hans Joergen T Guthe, MD

Haukeland University Hospital

More Information

No publications provided by Haukeland University Hospital

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Guthe HJ, Nedrebø T, Tenstad O, Wiig H, Berg A. Effect of topical anaesthetics on interstitial colloid osmotic pressure in human subcutaneous tissue sampled by wick technique. PLoS One. 2012;7(2):e31332. Epub 2012 Feb 14.

Responsible Party:	Ansgar Berg, Proffesor, Haukeland University Hospital
ClinicalTrials.gov Identifier:	NCT01044979 History of Changes
Other Study ID Numbers:	071223
Study First Received:	December 17, 2009
Last Updated:	December 17, 2012
Health Authority:	Norway:National Committee for Medical and Health Research Ethics

Keywords provided by Haukeland University Hospital:

Colloid osmotic pressure in interstitial fluid
Colloid osmotic pressure in plasma
Protein fractions in interstitial fluid

ClinicalTrials.gov processed this record on June 18, 2013

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