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Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Haukeland University Hospital
ClinicalTrials.gov Identifier:
NCT01044979
First received: December 17, 2009
Last updated: July 3, 2014
Last verified: July 2014
  Purpose

The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.


Condition
Colloid Osmotic Pressure

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma, a Methodological Study

Further study details as provided by Haukeland University Hospital:

Primary Outcome Measures:
  • Colloid osmotic pressure [ Time Frame: 60 and 90 minuttes after implanting wicks ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Serum and interstitial fluid


Enrollment: 50
Study Start Date: December 2009
Study Completion Date: September 2010
Primary Completion Date: September 2010 (Final data collection date for primary outcome measure)
Detailed Description:

Fluid loss from circulating plasma volume is one of the contributors of oedema formation. Measurement of colloid osmotic pressure (COP) both in plasma and in interstitial fluid can be utilised in planing of fluid therapy in patients with oedema. Different methods of sampling interstitial fluid are well validated in animal models, but not in human. Sampling of interstitial fluid by subcutaneous sewn wicks is a well-known method and can be painful. Local anaesthetics can reduce pain. By comparing interstitial fluid taken from areas with or without application of local anaesthetics, a possible influence in COP values can be detected.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy volunteers over 18 years.

Criteria

Inclusion Criteria:

  • Adults over 18 years

Exclusion Criteria:

  • Ongoing illness
  • Medication
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01044979

Locations
Norway
Haukeland University Hospital
Bergen, Norway, 5021
Sponsors and Collaborators
Haukeland University Hospital
Investigators
Principal Investigator: Hans Joergen T Guthe, MD Haukeland University Hospital
  More Information

No publications provided by Haukeland University Hospital

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Haukeland University Hospital
ClinicalTrials.gov Identifier: NCT01044979     History of Changes
Other Study ID Numbers: 071223
Study First Received: December 17, 2009
Last Updated: July 3, 2014
Health Authority: Norway:National Committee for Medical and Health Research Ethics

Keywords provided by Haukeland University Hospital:
Colloid osmotic pressure in interstitial fluid
Colloid osmotic pressure in plasma
Protein fractions in interstitial fluid

ClinicalTrials.gov processed this record on November 27, 2014