Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma
The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.
Colloid Osmotic Pressure
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma, a Methodological Study|
- Colloid osmotic pressure [ Time Frame: 60 and 90 minuttes after implanting wicks ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Serum and interstitial fluid
|Study Start Date:||December 2009|
|Study Completion Date:||September 2010|
|Primary Completion Date:||September 2010 (Final data collection date for primary outcome measure)|
Fluid loss from circulating plasma volume is one of the contributors of oedema formation. Measurement of colloid osmotic pressure (COP) both in plasma and in interstitial fluid can be utilised in planing of fluid therapy in patients with oedema. Different methods of sampling interstitial fluid are well validated in animal models, but not in human. Sampling of interstitial fluid by subcutaneous sewn wicks is a well-known method and can be painful. Local anaesthetics can reduce pain. By comparing interstitial fluid taken from areas with or without application of local anaesthetics, a possible influence in COP values can be detected.