Developing a New, Dynamic, Therapeutic Pacemaker Algorithm for Stabilising Periodic Breathing in Chronic Heart Failure.
Recruitment status was Recruiting
To evaluate whether cardiac output manipulation via a cardiac pacemaker can stabilise ventilation.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
|Official Title:||Developing a New, Dynamic, Therapeutic Pacemaker Algorithm for Stabilising Periodic Breathing in Chronic Heart Failure.|
- stability of ventilation [ Time Frame: Per second ] [ Designated as safety issue: No ]
|Study Start Date:||January 2010|
|Estimated Study Completion Date:||October 2010|
|Estimated Primary Completion Date:||February 2010 (Final data collection date for primary outcome measure)|
Device: Pacemaker manipulation
Many patients with heart failure exhibit a distinctive abnormal cyclical breathing pattern, 'periodic breathing'. This means that patients have a worse prognosis and they have debilitating symptoms including breathlessness, fatigue and disrupted sleep. Many of these patients also have cardiac pacemakers fitted, to improve their heart function. We have discovered a new physiological mechanism linking the heart and lungs, and have shown that by changing the programmed settings of a cardiac pacemakers, we can change a patient's breathing. If we increase the programmed pacing heart rate, we increase the rate of delivery of carbon dioxide to the lungs temporarily, which increases ventilation. When we reduce the programmed pacing heart rate, the converse happens. We aim to demonstrate this phenomenon scientifically, and to use this information to stabilise periodic breathing in heart failure patients using pacemakers. We then plan to continue to investigate whether we can show that sleep quality is improved in heart failure patients with periodic breathing, by our pacing protocol.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01044407
|Contact: Darrel P Francis, MD||+44 firstname.lastname@example.org|
|Imperial NHS Trust||Recruiting|
|London, United Kingdom, W2 1NY|
|Principal Investigator: Darrel P Francis, MD|
|Principal Investigator:||Darrel P Francis, MD||Imperial College London|