ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?
This study is currently recruiting participants.
Verified June 2011 by Wolfson Medical Center
Sponsor:
Wolfson Medical Center
Information provided by:
Wolfson Medical Center
ClinicalTrials.gov Identifier:
NCT01041339
First received: December 30, 2009
Last updated: August 16, 2011
Last verified: June 2011
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Purpose
A blood test (2-3 cc peripheral venous blood) drawn /used from already available required lab tests to distinguish between pericarditis accompanied with electrocardiogram (ECG) signs mimicking infarction. A test of clinical potential if proven to be able to support either origin of acute chest pain etiology.
| Condition |
|---|
|
Acute Chest Syndrome |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | ST Elevation (Acute Coronary Syndrome Versus Pericarditis;Could Measurement of Lp-associated PLA2 -a Vascular Specific Marker of Inflammation- be Helpful to the Clinician? |
Resource links provided by NLM:
Further study details as provided by Wolfson Medical Center:
Biospecimen Retention: Samples Without DNA
Detailed Description:
plasma kept in -80 celsius refrigerator
| Estimated Enrollment: | 100 |
| Study Start Date: | January 2010 |
| Estimated Study Completion Date: | January 2012 |
| Estimated Primary Completion Date: | November 2011 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
acute chest pain ST elevation
patients admitted with acute chest pain sharing ST elevation in ER-ECG and elevated troponin
|
|
controls
asymptomatic patients
|
Detailed Description:
Too many times young patients presenting with acute chest pain are referred to invasive angiography or treated with anticoagulation therapy a measure of detrimental effect in those inflicted with acute pericarditis.
A simple blood test (the PLAC test) may have some value in aiding rapid diagnosis saving need for cath.
Eligibility| Ages Eligible for Study: | 18 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
acute chest pain patients admitted to ICCU with acute ST elevation and elevated troponin
Criteria
Inclusion Criteria:
- acute chest pain
- acute ST elevation
- elevated troponin I
Exclusion Criteria:
- patients with recent (> 24 hour chest pain) myocardial infarction
- refusing to provide blood samples
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01041339
Contacts
| Contact: alexander J izhaki, MD | 0508916027 | alex.izhaki@gmail.com |
| Contact: yoseph rozenmam, MD | 97235028404 | rozenman@wolfson.health.gov.il |
Locations
| Israel | |
| The E.Wolfson MC | Recruiting |
| Holon, Israel, 52100 | |
| Contact: alexander J izhaki, MD 972-3-5028333 alex.izhaki@gmail.com | |
| Principal Investigator: alexander J izhaki, MD | |
Sponsors and Collaborators
Wolfson Medical Center
Investigators
| Principal Investigator: | Alexander J Izhaki, MD | The E.Wolfson MC |
More Information
Additional Information:
No publications provided
| Responsible Party: | Alexander Izhaki MD, Heart Institute , The E. Wolfson MC |
| ClinicalTrials.gov Identifier: | NCT01041339 History of Changes |
| Other Study ID Numbers: | 0075-09-WOMC |
| Study First Received: | December 30, 2009 |
| Last Updated: | August 16, 2011 |
| Health Authority: | Israel: Ethics Commission |
Keywords provided by Wolfson Medical Center:
|
LpPLA2 ST elevation acute pericarditis |
Additional relevant MeSH terms:
|
Pericarditis Acute Chest Syndrome Acute Coronary Syndrome Heart Diseases Cardiovascular Diseases Lung Diseases Respiratory Tract Diseases Respiration Disorders Anemia, Sickle Cell Anemia, Hemolytic, Congenital Anemia, Hemolytic |
Anemia Hematologic Diseases Hemoglobinopathies Genetic Diseases, Inborn Myocardial Ischemia Angina Pectoris Vascular Diseases Chest Pain Pain Signs and Symptoms |
ClinicalTrials.gov processed this record on May 19, 2013