Polymorphism of Estrogen Genes in Stroke

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2010 by Taipei Medical University WanFang Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Taipei Medical University WanFang Hospital
ClinicalTrials.gov Identifier:
NCT01040182
First received: December 27, 2009
Last updated: December 1, 2010
Last verified: December 2010
  Purpose

The purpose of this study is to explore the association between the genetic polymorphisms of estrogen-related genes, including estrogen synthesis, metabolizing, and receptor genes, and ischemic stroke. Furthermore, independent and joint effects of traditional risk factors and estrogen related genes on risk of stroke in young adults will also be examined in this study.


Condition
Ischemic Stroke

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Polymorphism of Estrogen Genes in Stroke

Resource links provided by NLM:


Further study details as provided by Taipei Medical University WanFang Hospital:

Biospecimen Retention:   Samples With DNA

Buffy coat and plasma will be retained.


Estimated Enrollment: 300
Study Start Date: December 2009
Estimated Study Completion Date: November 2010
Estimated Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
ischemic stroke patients
healthy subjects without cerebrovascular disease

Detailed Description:

Cerebrovascular diseases are the third leading cause of death in Taiwan in 2007. It is also the most important reason for disability among elderly adults. Sex hormones are well reported to be associated with cardiovascular disease risk. Several studies showed that estrogens have been shown to have beneficial effects on the cardiovascular system via favorable effects on anti-inflammatory effects. Genetic polymorphisms of estrogen related genes are speculated to influence estrogen level and will count for human susceptible to risk of stroke in young adults. In addition, several studies showed that the decrease in estrogen-induced vascular inflammatory markers including adhesion molecules and chemokines might be the mechanism for vascular protection. Recently, a novel and unique mechanisms for 17β-Estradiol (E2) anti-inflammatory activity which is E2 prevents inflammatory gene transcription induced by inflammatory agents by inhibiting NF-κB intracellular transport was found. Therefore, we proposed a study to explore the association between the genetic polymorphisms of estrogen-related genes, including estrogen synthesis, metabolizing, receptor genes, and NF-κB and ischemic stroke in young adults.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

A total of 300 incident ischemic stroke patients will be recruited in the program project.

Criteria

Inclusion Criteria:

  • incident ischemic stroke patients diagnosed by CT or MRI.

Exclusion Criteria:

  • non ischemic stroke patients
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01040182

Locations
Taiwan
WanFang Hospital Recruiting
Taipei, Taiwan
Contact: Hung-Yi Chiou, Ph.D.    886-2-27361661 ext 6512    hychiou@tmu.edu.tw   
Sub-Investigator: Chin-I Chen, M.D.         
Sponsors and Collaborators
Taipei Medical University WanFang Hospital
Investigators
Principal Investigator: Hung-Yi Chiou Taipei Medical University WanFang Hospital
  More Information

No publications provided

Responsible Party: Hung-Yi Chiou, Ph.D./PI, National Science Council
ClinicalTrials.gov Identifier: NCT01040182     History of Changes
Other Study ID Numbers: NSC 97-2321-B-038-002
Study First Received: December 27, 2009
Last Updated: December 1, 2010
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Taipei Medical University WanFang Hospital:
ischemic stroke patients

Additional relevant MeSH terms:
Stroke
Cerebral Infarction
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Brain Infarction
Brain Ischemia
Estrogens
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on September 29, 2014