Optimizing Toxicological Screening in Drug Endangered Children

This study has been completed.
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT01037569
First received: December 19, 2009
Last updated: March 23, 2011
Last verified: March 2011
  Purpose

Background:

  • Children who enter the foster care system are all too often exposed to illicit drugs in the home. Children from these homes, known as drug endangered children, are not routinely tested for harmful substances. Any short- and long-term physical or developmental problems they may experience as a result of this exposure often go undetected and untreated.
  • Children who are placed into protective custody are not always screened by physicians or nurse practitioners. Although drug-endangered children under 18 years of age automatically receive a urine toxicology screen to determine the types and levels of illicit drugs in their systems, this procedure has difficulties and limitations that may affect the quality of the data. Researchers are interested in developing more effective methods of analyzing the presence or absence of illicit environmental drug exposure in children.

Objectives:

- To determine the most effective method of identifying long-term illicit stimulant drug exposure in drug-endangered children.

Eligibility:

- Children under 18 years of age who are being placed into protective custody after having been found in a home where drugs are manufactured, used, or sold.

Design:

  • Researchers will gain verbal consent for the procedure for children who are 7 years of age or older. Children younger than 7 years of age will not be required to give verbal consent for sample collection.
  • Researchers will collect standard urine samples for toxicological screening. Part of the sample will be sent to the National Institute on Drug Abuse for evaluation; the rest will remain with the local authority.
  • In addition to this standard procedure, researchers will collect a hair sample by cutting a small amount of hair from the crown of the head as close to the root as possible (and not pulling any hair out of the child's head).
  • Researchers will also use an oral swab to collect a saliva sample from the inside cheek of each child.
  • No clinical care will be provided under this protocol....

Condition
Substance Abuse Detection

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Optimizing Toxicological Screening in Drug Endangered Children

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 100
Study Start Date: July 2007
Estimated Study Completion Date: March 2011
Detailed Description:

This is a single-center, investigator-initiated study to determine the best method for analyzing the presence or absence of illicit environmental drug exposure in children placed into protective custody in Sacramento County. In collaboration with the National Institutes of Health (NIH), National Institute of Drug Abuse (NIDA) we will use diagnostic procedures to determine the presence of illicit drugs in the following three samples: (1) hair; (2) oral swab; and (3) urine. These samples will be sent to a designated NIH lab site where 100 de-identified samples will be analyzed for methamphetamine, amphetamine, Ecstasy (MDMA), and MDEA.

  Eligibility

Ages Eligible for Study:   1 Year to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria
  • ELIGIBILITY CRITERIA:

Inclusion criteria are the following (and must have all of the following):

  1. children under the age of 18 (the vast majority - 87 percent - of children examined at the Center are under the age of 6);
  2. children placed into protective custody by Sacramento County CPS or law enforcement;
  3. children examined at the CAARE Center; and
  4. children found in a home where drugs are manufactured, used and/or sold.

Exclusion criteria are the following (any one of the following may apply):

  1. anyone who has reached the age of majority;
  2. those found to have parents who are not drug abusers;
  3. those where there was no definitive evidence of environmental drug exposure (i.e., suspicious parent, but no drugs were found in the home); or
  4. any child, drug exposed or not, who is examined in the UCD Emergency Department (after hours - 9:00 pm to 7:00 am - and weekends).
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01037569

Locations
United States, California
University of California, Davis
Davis, California, United States, 95616
Sponsors and Collaborators
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT01037569     History of Changes
Other Study ID Numbers: 999907431, 07-DA-N431
Study First Received: December 19, 2009
Last Updated: March 23, 2011
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Toxicological Screening
Drugs
Alternative Matrices
Urine
Children

ClinicalTrials.gov processed this record on October 22, 2014