Genetic & Pathological Studies of BRCA1/BRCA2: Associated Tumors & Blood Samples
This study is currently recruiting participants.
Verified May 2013 by Stanford University
Information provided by (Responsible Party):
First received: December 16, 2009
Last updated: May 28, 2013
Last verified: May 2013
- To establish a demographic database to evaluate the efficacy of medical interventions in patients and relatives who carry BRCA1 and 2 mutations and to compare these outcomes to patients who do not carry a BRCA1 or 2 mutation.
- To obtain blood samples from patients who undergo genetic testing to a) evaluate the incidence of genetic modifier polymorphisms involved in the development of cancer in BRCA1 and 2 mutation carriers and to compare this incidence to non-BRCA 1 and 2 carriers. b) to understand the interaction of genetic modifiers and BRCA1 and 2 in the development of cancer. c) to determine the effect of environmental influences on the incidence of polymorphisms in genetic modifiers and on the penetrance of BRCA1 and 2 mutations by linking information from our demographic database to blood samples and
- To obtain tumor tissue from BRCA1 and 2 carriers to utilize for gene expression studies.
- To establish a cohort of sporadic breast cancer patients, or women with no family history of cancer in a first degree relative, to serve as a comparison group to women with strong family history of breast cancer.
- To establish a cohort of healthy volunteers without personal or family history of cancer to serve as a comparison group to women with sporadic and familial breast cancer.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Genetic & Pathological Studies of BRCA1/BRCA2: Associated Tumors & Blood Samples|
Resource links provided by NLM:
U.S. FDA Resources
Further study details as provided by Stanford University:
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01034033
|Contact: Meredith Mills||(650) firstname.lastname@example.org|
|United States, California|
|Stanford University School of Medicine||Recruiting|
|Stanford, California, United States, 94305|
|Contact: Meredith Mills 650-724-5223 email@example.com|
|Principal Investigator: James M Ford|
|Sub-Investigator: Hanlee P. Ji|
|Sub-Investigator: Vandana Bhardwaj Sharma|
|Sub-Investigator: Patrick O. Brown|
|Sub-Investigator: Maria Gramatges|
|Sub-Investigator: Allison Walsh Kurian|
Sponsors and Collaborators
|Principal Investigator:||James M Ford||Stanford University|