Study of Atenolol Influence on Blood Pressure During Resistance Exercise

This study has been completed.
Fundação de Amparo à Pesquisa do Estado de São Paulo
Information provided by:
University of Sao Paulo Identifier:
First received: December 8, 2009
Last updated: December 14, 2009
Last verified: May 2009

The study was designed to investigate if atenolol is able to blunt blood pressure increase during resistance exercise in hypertensive subjects.

Condition Intervention Phase
Blood Pressure
Drug: atenolol
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Supportive Care
Official Title: Blood Pressure Response During Resistance Exercise in Hypertensives: Influence of Beta-blockers

Resource links provided by NLM:

Further study details as provided by University of Sao Paulo:

Primary Outcome Measures:
  • blood pressure during resistance exercise [ Time Frame: 6 weeks ] [ Designated as safety issue: Yes ]

Enrollment: 10
Study Start Date: May 2007
Study Completion Date: May 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: atenolol
subjects received 6 weeks of atenolol
Drug: atenolol
25 mg/day, twice a day for 6 weeks
Other Name: beta-blockers

Detailed Description:

The study compared intra-arterial blood pressure responses during leg-extension resistance exercise performed to fatigue at 40, 80 and 100% of 1 RM in hypertensive patients receiving placebo (first) and atenolol (second) on a single blind manner.


Ages Eligible for Study:   30 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • hypertension with blood pressure levels below 160/105 mmHg under placebo.
  • age between 30 and 60 years
  • nonobese

Exclusion Criteria:

  • target organ lesion
  • cardiovascular risk factor
  • cardiovascular disease
  • physically active
  Contacts and Locations
Please refer to this study by its identifier: NCT01030016

University of São Paulo
São Paulo, Brazil, 05508030
Sponsors and Collaborators
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo
Principal Investigator: Cláudia LM Forjaz, PhD University of São Paulo
Study Chair: Decio Mion Jr, PhD University of São Paulo
  More Information

No publications provided

Responsible Party: Cláudia Lúcia de Moraes Forjaz, School of Physical Education and Sport, University of São Paulo Identifier: NCT01030016     History of Changes
Other Study ID Numbers: FAPESP-06/06356-8
Study First Received: December 8, 2009
Last Updated: December 14, 2009
Health Authority: Brazil: National Committee of Ethics in Research

Keywords provided by University of Sao Paulo:
resistance exercise
blood pressure

Additional relevant MeSH terms:
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Anti-Arrhythmia Agents
Cardiovascular Agents
Therapeutic Uses
Antihypertensive Agents
Autonomic Agents
Peripheral Nervous System Agents
Adrenergic beta-1 Receptor Antagonists processed this record on April 23, 2014