Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

This study has been completed.
Sponsor:
Collaborators:
Korea Healthcare Technology R&D Project
Korea Advanced Institute of Science and Technology
Information provided by:
Chungnam National University
ClinicalTrials.gov Identifier:
NCT01025024
First received: December 2, 2009
Last updated: NA
Last verified: December 2009
History: No changes posted
  Purpose

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.


Condition Intervention
Single-nucleotide Polymorphism (SNP) for Glaucoma
Genetic: SNP analysis of the DNA

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients Patients, A Single-nucleotide Polymorphism(SNP)Analysis for Primary Open Angle Glaucoma

Resource links provided by NLM:


Further study details as provided by Chungnam National University:

Primary Outcome Measures:
  • genotyping for the SNP associated with primary open angle glaucoma [ Time Frame: one year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns [ Time Frame: one year ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Peripheral blood sample


Enrollment: 1224
Study Start Date: January 2007
Study Completion Date: November 2009
Primary Completion Date: October 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
POAG group
Elevated intraocular pressure normal open angle glaucomatous optic nerve head abnormality glaucomatous visual field defect
Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
Normal control
Normal intraocular pressure No optic disc abnormality No visual field defect No significant ocular and systemic disease
Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample

Detailed Description:

Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

  Eligibility

Ages Eligible for Study:   30 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

patients with open angle glaucoma who visited glaocoma clinic of departemtn of Ophtalmology, Chungnam National University Hospital, Daejeon, south Korea

Criteria

Inclusion Criteria:

  • Clinical diagnosis of primary open angle glaucoma

Exclusion Criteria:

  • Primary open angle glaucoma combined with congenital ocular disease
  • Primary open angel glaucoma combined with other ocular disease
  • Significant systemic disease other than systemic hypertension and diabetes
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01025024

Locations
Korea, Republic of
Chungnam National University Hospital
Daejeon, Korea, Republic of, 301-721
Sponsors and Collaborators
Chungnam National University
Korea Healthcare Technology R&D Project
Korea Advanced Institute of Science and Technology
Investigators
Principal Investigator: Chang-sik Kim, professor Department of Ophthalmology, Chungnam National University Hospital
Study Chair: Changwon Kang, professor Korea Advanced Institute of Science and Technology
Study Director: Kyunglan Kim Department of Biological Sciences, Korea Advanced Institute of Science and Technology
  More Information

No publications provided

Responsible Party: Chang-sik Kim, professor, Department of Ophthalmology, College of Medicine, Chungnam National University
ClinicalTrials.gov Identifier: NCT01025024     History of Changes
Other Study ID Numbers: CNUH81510-886, A080587
Study First Received: December 2, 2009
Last Updated: December 2, 2009
Health Authority: South Korea: Korea Food and Drug Administration (KFDA)

Keywords provided by Chungnam National University:
SNP
single-nucleotide polymorphism
glaucoma
primary open angle glaucoma

Additional relevant MeSH terms:
Glaucoma
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases

ClinicalTrials.gov processed this record on August 20, 2014