Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement (HyTe-1)
The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Determinants of Perioperative Hyperglycaemia in Primary Hip and Knee Replacement|
- Occurrence (and severity) of hyperglycemia following primary hip or knee replacement [ Time Frame: 3 days (average) ] [ Designated as safety issue: No ]Follow-up covers postoperative hospital stay at the operating hospital, that lasts typically 2-5 days.
- Incidence of surgical-site infections [ Time Frame: 1 year ] [ Designated as safety issue: No ]
- Prevalence of glucose metabolism disorders and metabolic syndrome [ Time Frame: Baseline ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
plasma sample (one per patient, collected before surgery)
|Study Start Date:||December 2009|
|Study Completion Date:||September 2012|
|Primary Completion Date:||July 2011 (Final data collection date for primary outcome measure)|
Hip and knee replacements recipients
Osteoarthritis patients undergoing elective primary hip and knee replacement and being followed-up in this study.
Postoperative infections remain one of the most frequent reasons of failure of hip and knee prostheses. Diabetes increases the risk of infections. In other fields of surgery, hyperglycemia induced by surgical stress (stress/perioperative hyperglycemia) has been associated with higher rates of postoperative infections and complications. Such studies have not yet been performed in the field of joint replacement surgery. Unlike several other risk factors of infected joint replacements, hyperglycemia is potentially modifiable and therefore its prevalence, predisposing factors and association with postoperative infections are of interest.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01021826
|Coxa, Hospital for Joint Replacement|
|Tampere, Finland, 33580|
|Study Director:||Teemu Moilanen, MD, PhD||Coxa, Hospital for Joint Replacement|
|Principal Investigator:||Esa Jämsen, MD, PhD||Coxa, Hospital for Joint Replacement|
|Principal Investigator:||Pasi Nevalainen, MD, PhD||Tampere University Hospital|