Association Between Arterial Wall Uptake of Fluorodeoxyglucose on PET Imaging and sRAGE

This study has been completed.

Sponsor:

Information provided by:

Korea University

ClinicalTrials.gov Identifier:

NCT01021514

First received: November 27, 2009

Last updated: April 5, 2011

Last verified: April 2011

History of Changes

Purpose

Arteriosclerosis is a dynamic inflammatory disorder. Recently, FDG-PET CT is emerging diagnostic tool of non-invasive technique to detect vulnerable atherosclerotic plaque. And there are arising evidence that sRAGE(soluble Receptor for Advanced glycation End Product) is correlated with metabolic risk. So the investigators will investigate association between sRAGE and FDG-PET uptake in large artery in healthy patient.

Condition
sRAGE Level SUV and TBR Levels in FDG PET

Study Type:	Observational
Study Design:	Observational Model: Case Control Time Perspective: Cross-Sectional
Official Title:	Association Between Arterial Wall Uptake of Fluorodeoxyglucose on PET Imaging and sRAGE

Further study details as provided by Korea University:

Enrollment:	82
Study Start Date:	January 2009
Study Completion Date:	November 2010
Primary Completion Date:	August 2010 (Final data collection date for primary outcome measure)

Groups/Cohorts
Type 2 DM, Healthy control Type 2 DM patients are treating in the Diabetic Clinic of Korea university Guro hospital, and their age- and sex-matched healthy controls are underwent a routine health checkup at Korea university Guro hospital.
Type 2 DM, Heatlhy control

Eligibility

Ages Eligible for Study:	16 Years to 80 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

type 2 DM diagnoed according to critereia of American Diabetes Asociation.

Criteria

Inclusion Criteria:

Clinical diagnosis od type 2 DM

Exclusion Criteria:

Type 1 DM
Gestational Diabetes
Severe Liver or Renal disease
Diagnosis of cancer
Trauma
Acute infection or inflammatory disease
Acute vasculitis or history of vasculitis
Pregnant or Lactating women
Dyslipidemia(active state)
Cardiovascular disease or history of CVD
Chronic obstructive pulmonary disease
Any patient by judge of investigator

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01021514

Sponsors and Collaborators

Korea University

Investigators

Principal Investigator:

Kyoungmook Choi, MD, PhD

Korea University Guro Hospital

More Information

No publications provided by Korea University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Yang SJ, Kim S, Hwang SY, Kim TN, Choi HY, Yoo HJ, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM. Association between sRAGE, esRAGE levels and vascular inflammation: analysis with (18)F-fluorodeoxyglucose positron emission tomography. Atherosclerosis. 2012 Feb;220(2):402-6. Epub 2011 Nov 16.

Responsible Party:	Korea University Guro Hopital Endocrinology department, Korea University Guro Hospital
ClinicalTrials.gov Identifier:	NCT01021514 History of Changes
Other Study ID Numbers:	PET(RAGE)
Study First Received:	November 27, 2009
Last Updated:	April 5, 2011
Health Authority:	Korea: Food and Drug Administration

Keywords provided by Korea University:

sRAGE
SUV
TBR
FDG PET CT
Type 2 DM

ClinicalTrials.gov processed this record on June 17, 2013

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