Umbilical Cord Serum Eye Drops

This study has been completed.

Sponsor:

Information provided by:

Chonnam National University Hospital

ClinicalTrials.gov Identifier:

NCT01016158

First received: November 18, 2009

Last updated: NA

Last verified: November 2009

History: No changes posted

Purpose

In the present study, the investigators investigated the efficacy of umbilical cord serum eye drops for the treatment of patients with recurrent corneal erosions. Group A were treated with 20% umbilical cord serum eye drops 3 to 4 times a day in addition to artificial tears, and group B were treated with artificial tears only. Ophthalmic examinations including visual acuity measurement and slit lamp biomicroscopy were performed before and every month after treatment. Recurrence was defined as the presence of clinical symptoms accompanied by epithelial defects in the cornea.

Condition	Intervention
Recurrent Corneal Erosion	Drug: Umbilical cord serum eyedrops

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Outcomes Assessor) Primary Purpose: Treatment

Resource links provided by NLM:

Drug Information available for: Tetrahydrozoline hydrochloride Boric acid

U.S. FDA Resources

Further study details as provided by Chonnam National University Hospital:

Study Start Date:	April 2006
Study Completion Date:	October 2009
Primary Completion Date:	April 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: umbilical cord serum eyedrops patients with recurrent corneal erosions were treated with 20% umbilical cord serum eye drops 3 to 4 times a day in addition to artificial tears	Drug: Umbilical cord serum eyedrops 20% umbilical cord serum eye drops 3 to 4 times a day

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

patients with recurrent corneal erosions

Exclusion Criteria:

none

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01016158

Locations

Korea, Republic of
Chonnam National University Hospital
Gwang-Ju, Korea, Republic of

Sponsors and Collaborators

Chonnam National University Hospital

More Information

Publications:

Yoon KC, Im SK, Park YG, Jung YD, Yang SY, Choi J. Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome. Cornea. 2006 Apr;25(3):268-72.

del Castillo JM, de la Casa JM, Sardiña RC, Fernández RM, Feijoo JG, Gómez AC, Rodero MM, Sánchez JG. Treatment of recurrent corneal erosions using autologous serum. Cornea. 2002 Nov;21(8):781-3.

Yoon KC, You IC, Im SK, Jeong TS, Park YG, Choi J. Application of umbilical cord serum eyedrops for the treatment of neurotrophic keratitis. Ophthalmology. 2007 Sep;114(9):1637-42. Epub 2007 Mar 26.

Responsible Party:	Kyung-Chul Yoon
ClinicalTrials.gov Identifier:	NCT01016158 History of Changes
Other Study ID Numbers:	I-2009-11-135
Study First Received:	November 18, 2009
Last Updated:	November 18, 2009
Health Authority:	Korea: Institutional Review Board

Keywords provided by Chonnam National University Hospital:

Umbilical cord serum
Recurrent corneal erosion

Additional relevant MeSH terms:

Tetrahydrozoline
Nasal Decongestants
Vasoconstrictor Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions

Respiratory System Agents
Sympathomimetics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on May 21, 2013

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