Tear Film Thickness Measured Using a Novel Technique
The aim of this investigation is to determine the thickness of the human preocular tear film using a new method based on laser speckle. This will be a preliminary study to generate "normative" tear film thickness data in normal (i.e., non dry eye) and dry eye subjects in a clinic-based population. In addition, we will examine the short term (i.e., one week) repeatability of the method in a single setting.
The patients classified as having dry eye will also have their tear film thickness measured after instillation of an artificial tear. This will potentially reveal valuable data in retention of effect measured non-invasively as in prior studies that employed a fluorescein tracer.
|Study Design:||Time Perspective: Cross-Sectional|
|Official Title:||Tear Film Thickness Measured Using a Novel Technique|
- Tear film thickness in normal eyes [ Time Frame: 1-3 months ] [ Designated as safety issue: No ]
- Tear thickness change following viscous drop instillation [ Time Frame: 1-3 months ] [ Designated as safety issue: No ]
|Study Start Date:||November 2009|
|Study Completion Date:||October 2010|
|Primary Completion Date:||April 2010 (Final data collection date for primary outcome measure)|
Normal (non-dry) dry eye subjects
These are healthy individuals, age 18 and above, who do not exhibit dry eyes by signs and symptoms
Dry eye subjects
These are subjects, age 18 years and above, who do exhibit signs and symptoms of dry eye.
We will generate "normative" tear thickness data in normal (i.e., not dry) and dry eyes in human subjects. We will examine short-term repeatability of the method, and we will examine the influence on tear thickness of a viscous eyedrop instilled into the eye.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01014780
|United States, California|
|Southern California College of Optometry|
|Fullerton, California, United States, 92831`|
|Study Director:||Jerry Paugh, OD. PhD||Southern California College of Optometry|