Cardiovascular Risk Factors After Renal Transplantation in Children and Adults (HENT)
Recruitment status was Active, not recruiting
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Purpose
Renal transplantation of children started in Norway in 1970.Since the beginning, >80% of renal transplants are provided from Living Donors(mainly parents), short pre-transplant dialysis time( median 4 months) and 50% of transplantations are performed before dialysis is needed.This gives good premises for graft survival and avoidance of detrimental effects of dialysis. However, renal transplanted children are subjected to an increased cardiovascular morbidity and mortality in adulthood due to consequences of chronic renal failure and immunosuppressive treatment.Cardiovascular death comprises 30-40% of death causes. In this cross-sectional study we evaluate cardiovascular risk factors in childhood- and also in young adults renal transplanted in childhood.
Focus is cardiorespiratory fitness using treadmill testing,24h BP measurements, anthropometrics including waist circumference,echocardiography,intima media thickness of carotids, glucose intolerance test.Participants are also requested to fill out physical activity recalls and Quality of life questionnaires.
| Condition |
|---|
|
Exercise Capacity Physical Activity Hypertension Overweight and Obesity Metabolic Syndrome |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Cross-Sectional |
| Official Title: | Outcome After Pediatric Renal Transplantation: Cardiorespiratory Fitness, Cardiovascular Risk Factors and Quality of Life |
- other cardiovascular risk factors [ Time Frame: 2007-2010 ] [ Designated as safety issue: No ]
- hypertension [ Time Frame: 2007-2010 ] [ Designated as safety issue: No ]
- impaired glucose intolerance [ Time Frame: 2007-2010 ] [ Designated as safety issue: No ]
- left ventricular hypertrophy, [ Time Frame: 2007-2010 ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Freezing of serum and plasma from study participants
| Estimated Enrollment: | 60 |
| Study Start Date: | June 2007 |
| Estimated Primary Completion Date: | June 2010 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Renal transplanted children and young adults
Renal transplanted children and adolescents (2-18yrs) transplanted between 1993-2006. Renal transplanted young adults aged 20-35 yrs old, transplanted from 1983 onwards. |
Eligibility| Ages Eligible for Study: | 2 Years to 38 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Renal transplanted children, adolescents and young adults transplanted in the period 1983-2006 in the same center (Oslo University Hospital, Rikshospitalet)
Inclusion Criteria:
- Transplanted after 1983, functioning graft
Exclusion Criteria:
- Patients in dialysis
- In part of the study concerning treadmill testing: Age<8 years, orthopedic limitations
Contacts and Locations More Information
No publications provided
| Responsible Party: | Oslo University Hospital, Rikshospitalet HF, Rikshospitalet HF, department of pediatrics |
| ClinicalTrials.gov Identifier: | NCT01008306 History of Changes |
| Other Study ID Numbers: | S-07245b |
| Study First Received: | November 3, 2009 |
| Last Updated: | November 4, 2009 |
| Health Authority: | Norway:National Committee for Medical and Health Research Ethics |
Keywords provided by Oslo University Hospital:
|
Cardiorespiratory fitness physical activity hypertension |
overweight and obesity metabolic syndrome Body composition |
Additional relevant MeSH terms:
|
Hypertension Obesity Overweight Metabolic Syndrome X Vascular Diseases Cardiovascular Diseases Overnutrition |
Nutrition Disorders Body Weight Signs and Symptoms Insulin Resistance Hyperinsulinism Glucose Metabolism Disorders Metabolic Diseases |
ClinicalTrials.gov processed this record on May 23, 2013